参苓白术散抗溃疡性结肠炎的物质基础、作用机制及安全性评价

Progress on the Material Basis,Mechanism of Action and Safety Evaluation of Shenling Baizhu Powder Against Ulcerative Colitis

溃疡性结肠炎(ulcerative colitis,UC)是一种结、直肠的慢性非特异性炎症性肠病,因病症长、反复发作、缠绵难愈,被公认为难治疾病之一,且已被证实为结肠癌的癌前病变。中医认为,脾虚湿困是UC的常见病机,健脾祛湿经典方参苓白术散中的人参、茯苓、山药等均属药食同源中药,不良反应少、安全性较高,在治疗UC等复杂慢性疾病有显著优势。本文对近些年参苓白术散抗UC的物质基础和作用机制研究进行综述,并探讨了其在药食同源方面的应用和安全性,可望为参苓白术散在治疗UC中的临床应用和食用保健提供理论依据。

Ulcerative colitis(UC)is a chronic non-specific inflammatory bowel disease of the colon and rectum,which is recognized as one of the refractory diseases due to its long,recurrent and lingering symptoms,and has been confirmed to be a precancerous lesion of colon cancer.Traditional Chinese medicine believes that spleen deficiency and dampness are the common pathogenesis of UC,and ginseng,poria,and yam in the classic formula Shenling Baizhu Powder for strengthening spleen and dampness are all food homologous Chinese medicines with few adverse reactions and high safety,which have significant advantages in the treatment of complex chronic diseases such as UC.This article reviews the research on the material basis and mechanism of action of Shenling Baizhu Powder against UC in recent years,and discusses its application and safety in the homology of medicine and food,which is expected to provide a theoretical basis for the clinical application and food health care of Shenling Baizhu Powder in the treatment of UC.