生活习惯对非酒精性脂肪肝病的影响

Influence of lifestyle habits on nonalcoholic fatty liver disease

近年来,社会经济蓬勃发展,人们的生活方式也相应发生了一些改变.经过科学研究和医学实践证实,人们在饮食结构、身体活动、睡眠模式以及心理状态等各方面的改变,均会对个体的身体健康产生深远影响.这些改变,尤其是不良的身体活动方式和饮食习惯,已经逐渐威胁到人们的身体健康.非酒精性脂肪肝病,作为一种慢性肝病,其发病率正逐年上升,与这些不健康的生活方式密切相关.久坐不动、膳食中脂质和胆固醇含量过高等均与非酒精性脂肪肝病的发病率呈现出高度的相关性.值得注意的是,迄今为止,在美国和欧盟尚无药物获批用于治疗该病.因此,我们更需要关注非药物治疗策略,特别是通过改变不良的身体活动方式和饮食模式来预防和缓解这一疾病.为此,本文将深入讨论不同饮食模式和身体活动方式对肝脏物质代谢的影响,阐明其分子机制,以期为非酒精性脂肪肝病提供切实有效的非药物治疗策略.

In recent years,there has been a booming social and economic development,and people's lifestyles have also undergone some changes accordingly.Scientific research and medical practice have confirmed that changes in people's dietary structure,physical activity,sleep patterns and psychological state have far-reaching effects on individual health.These changes,especially poor physical activity and dietary habits,have gradually threatened people's health.Non-alcoholic fatty liver disease(NAFLD),a chronic liver disease whose incidence is increasing year by year,is closely related to these unhealthy lifestyles.Sedentary lifestyle,excessive dietary fat and cholesterol content,etc.all show a high correlation with the incidence of NAFLD.It is worth noting that,to date,no drugs have been approved for the treatment of this disease in the United States and the European Union.Therefore,there is a greater need to focus on non-pharmacological treatment strategies,especially to prevent and alleviate this disease by modifying poor physical activity patterns and dietary patterns.To this end,this article will discuss in depth the effects of different dietary and physical activity patterns on hepatic substance metabolism and elucidate their molecular mechanisms,with a view to providing effective nonpharmacological therapeutic strategies for non-alcoholic fatty liver disease.