RNA及翻译后修饰在肠道病毒感染与致病中的研究进展

Progress in the roles of RNA and post-translational modifications in enterovirus infection and pathogenesis

肠道病毒(enterovirus,EV)是一群病原体结构及致病机制高度相似但可引起人类多种疾病的重要RNA病毒,目前仍严重威胁着人类健康。EV与宿主互作中发生的生物学事件是学术界探究EV致病机制及开发相关防治策略始终绕不开的核心主题。由于组学技术的更新,EV及宿主的RNA修饰和蛋白质翻译后修饰(post-translational modifications,PTM)在近些年得到广泛关注并取得了部分成果,为精准靶向各修饰开发防治EV相关疾病的策略带来了新曙光。本文就EV-宿主互作中相关RNA修饰及蛋白PTM的研究进展进行概述,以期增强对EV感染与致病机制的理解并为临床转化研究提供有益参考。

Enterovirus(EV)includes a group of important RNA viruses with similarity in viral structure and pathogenesis.They can cause various diseases in humans and pose a great threat to human health.The biological events that occur in EV-host interactions are the core topics to be investigated for better understanding the pathogenesis of EV and developing related prevention and treatment strategies.With the development of genomics technologies,RNA modifications and protein post-translational modifications(PTM)in EV and its hosts have drawn much attention and some achievements have been made,which may shed light on developing precise strategies for the prevention and control of EV-associated diseases.In this paper,to better understand the pathogenesis of EV infection and provide reference for clinical translational research,the progress in the roles of RNA modifications and protein PTM in EV-host interactions are summarized.