基于活体微生物及其衍生物的抗细菌感染策略研究进展

Research advances of living microorganisms and their derivatives-based strategies for the treatment of bacterial infection

近年来,抗生素滥用导致治疗过程出现细菌感染耐受,而耐药菌感染会造成的发病率及死亡率大幅提高。由于药物递送系统能够被精准设计,实现药物的可控释放,从而能降低抗生素毒不良反应与耐药风险,因此,可以寻求新型药物递送系统以应对细菌感染带来的挑战。本综述首先概述细菌感染流行与防控现状,并进一步围绕微生物天然特性如表面特异性蛋白、生理信号感应、定向运动、抗菌物质分泌等方面系统梳理并总结了近些年报道的活体微生物及其衍生物递药系统,及它们如何发挥抗菌作用的作用机制,揭示了基于活体微生物及其衍生物的递药系统在细菌感染类疾病的治疗中显示的巨大应用潜力。本综述旨在为开发基于活体微生物及其衍生物的新型递药系统用于治疗细菌感染类疾病提供思路。

In recent years,the abuse of antibiotics has led to antibiotic tolerance in the process of bacterial treatment,the morbidity and mortality caused by drug-resistant bacterial infection have further increased significantly.Drug delivery systems can be precisely designed to achieve controlled drug release,thereby reducing the risk of antibiotic toxicity and resistance,it is urgent to seek novel drug delivery systems to address the challenges posed by bacterial infections.This review first outlines the epidemic and prevention situation of bacterial infection,and further summarizes living microorganisms and their derivatives-based drug delivery systems,focusing on their natural characteristics such as surface specific proteins,physiological signal sensing,directed movement,and secretion of antibacterial substances,which show great potential in the treatment of bacterial infectious diseases by demonstrating their antibacterial effects.This review aims to provide ideas for the development of novel drug delivery systems based on living microorganisms and their derivatives for the treatment of bacterial infectious diseases.