转录因子对丹参酮类物质调控作用及机制研究进展

Research progress in regulation and mechanism of transcription factors on tanshinones

丹参是临床常用的活血化瘀药,主要用于心脑血管疾病的治疗,其关键活性物质丹参酮的合成和调控机制一直为研究热点。本文对近年来有关转录因子(AP2/ERF、bHLH、MYB、bZIP、WRKY等)调节丹参酮类成分生物合成的研究成果进行了归纳总结,指出了丹参转录调控研究存在的问题,探讨了转录因子在丹参酮类活性成分生物合成调控中的研究方向,为进一步发现和利用丹参酮类活性物质调控功能基因提供理论依据。

Salvia miltiorrhiza,a commonly used traditional Chinese medicine,has been widely recognized for its blood-activating and stasis-removing properties in the clinical treatment of cardiovascular and cerebrovascular diseases.The synthesis and regulatory mechanism of tanshinones,the key active constituents of Salvia miltiorrhiza,have been a hot topic of research.The paper summarized the research findings on the regulation of tanshinone biosynthesis by transcription factors such as AP2/ERF,bHLH,MYB,bZIP,and WRKY in recent years.The review identifies the existing issues in the transcriptional regulation studies of Salvia miltiorrhiza and discusses the research direction of transcription factors in the regulation of tanshinone biosynthesis,providing a theoretical basis for the further discovery and utilization of functional genes involved in the regulation of tanshinone bioactive constituents.