高分子医用材料设计性实验教学探索——以“光固化3D打印立体网络水凝胶支架”为例

Exploration on Designing Experiment Teaching of Polymer Medical Materials——Taking“Three-dimensional Network Hydrogel Scaffold Made by Photocuring 3D Printing”as an Example

将前沿性的科学技术引入本科实验教学已成为高校教学改革的趋势之一。3D打印作为一种新兴的制造技术,在高分子材料成型加工领域具有良好的应用价值。在生物医用材料方面,通过3D打印可以设计并制备出与患者受损组织区域相同或相似的三维修复材料,以实现精准化和个性化医疗。结合生物医药特色,学院开展了以3D打印高分子医用材料为研究主题的设计性实验教学项目,为学生提供自主学习和实践的平台。本文采用数字光处理(DLP) 3D打印技术对光敏材料甲基丙烯酰化明胶(GelMA)和聚乙二醇二丙烯酸酯(PEGDA)进行光固化处理,制备三维网络水凝胶支架,打印的样品结构完整,孔道连通,孔径与模型相符。分析空间结构和材料配方对水凝胶支架性能的影响,结果显示500μm孔径的GelMA-PEGDA立体网络水凝胶具有较好的力学性、溶胀性以及稳定性。该设计性实验涉及多学科知识交叉融合,为师生带来了一种全新的教学体验,也为创新型人才的培养提供了一种新的思路。

Introducing cutting-edge science and technology into undergraduate experiment teaching has become one of the trends of education reform in colleges and universities.As a new manufacturing technology,photocuring 3D printing shows good application value in polymer material field.In terms of biomedical materials,3D printing is used to design and prepare 3D repair materials that are identical or similar to the damaged tissue area of the patient to achieve precision and personalized medicine.Combined with the biomedical characteristics,the school has implemented a designing experiment teaching project themed on 3D printing polymer medical materials,which provided students with a platform of independent learning and practicing.In this study,the photosensitive materials methacrylamide-modified gelatin(GelMA)and polyethylene glycol diacrylate(PEGDA)were light-cured by digital light processing(DLP)3D printing technology to prepare three-dimensional network hydrogel scaffolds.The printed samples had complete structure and interconnected channels,and their pore size was consistent with the 3D model.The effects of space structure and material formula on the properties of hydrogel scaffolds were analyzed.The results showed that the GelMA-PEGDA hydrogel with three-dimensional network and a pore size of 500μm had good mechanical property,swelling behavior,and stability.This designing experiment involved an integration of multidisciplinary knowledge,which not only brought a novel teaching experience for teachers and students,but also provided a new idea for the training of innovative talents.