CalliSpheres载药微球联合碘化油治疗肝癌的临床研究

Clinical study of CalliSpheres drug-loaded microspheres combined with iodized oil in the treatment of livercancer

目的探索国产血管栓塞微球(CalliSpheres)载药联合碘化油在肝癌中应用的临床疗效及安全性。方法回顾性分析我院收治的80例肝癌患者病例资料,按照不同治疗方法将其分为对照组(碘化油治疗)和联合组(CalliSpheres载药微球联合碘化油治疗),每组各40例,采用SPSS26.0统计学软件进行数据分析。观察两组患者术前、术后肝肾功能指标、血常规、凝血指标;术后不良反应及并发症;术后1个月、3个月、6个月肿瘤反应率。结果两组患者手术前肝功能比较,差异无统计学意义(P>0.05);术后7d,两组患者ALT、AST、TBIL比术前升高,ALB比术前低(P<0.05);术后1个月,两组患者ALB有所升高,但仍低于术前(P<0.05),而ALT、AST、TBIL基本恢复至术前水平(P<0.05)。术后1个月,联合组0RR、DCR分别为92.5%、95.0%,均高于对照组的82.5%、92.5%,但两组间无显著差异(P>0.05);术后3个月,两组ORR、DCR均降低,但联合组ORR、DCR分别为90.0%、92.5%,均高于对照组的65.0%、85.0%(P<0.05)。两组患者均未出现并发症,联合组与对照组患者腹痛、发热、恶心、呕吐发生率比较差异无统计学意义(P>0.05)。结论CalliSpheres载药微球联合碘化油治疗肝癌安全、有效。

Objective To explore the clinical efficacy and safety of CalliSpheres combined with iodized oil in liver cancer.Methods The data of 80 patients with liver cancer treated in our hospital were retrospectively analyzed,and they were divided into control group(iodized oil treatment)and combination group(CalliSpheres drug-loaded microspheres combined with iodized oil treatment)according to different treatment methods,with 40 cases in each group.SPSS 26.0 statistical software was used for data analysis.Liver and kidney function indexes,blood routine and coagulation indexes were observed before and after operation in 2 groups.Postoperative adverse reactions and complications;Tumor response rate at 1 month,3 months and 6 months after surgery.Results There was no significant difference in liver function between the two groups before operation(P>0.05).On day 7 after surgery,ALT,AST and TBIL were higher than before surgery,while ALB was lower than before surgery(P<0.05).One month after surgery,ALB was increased in both groups,but it was still lower than before surgery(P<0.05),while ALT,AST and TBIL basically recovered to pre-surgery levels(P<0.05).One month after operation,the ORR and DCR of the combined group were 92.5%and 95.0%,respectively,higher than 82.5%and 92.5%of the control group,but there was no significant difference between the two groups(P>0.05).Three months after operation,the ORR and DCR of the two groups were decreased,but the ORR and DCR of the combined group were 90.0%and 92.5%,respectively,which were higher than 65.0%and 85.0%of the control group(P<0.05).There were no complications in the two groups,and there was no significant difference in the incidence of abdominal pain,fever,nausea and vomiting between the combined group and the control group(P>0.05).Conclusion CalliSpheres drug-loaded microspheres combined with iodized oil are safe and effective in the treatment of liver cancer.