摘要
The phenomenon in which cells prefer glycolysis to oxidative phosphorylation with increased lactate production is known as the Warburg effect and is found prevalent in cancer cells and pluripotent stem cells [1]. In addition to being an intermediate metabolite of glycolysis, lactate has been reported as a signal involved in multiple important biological processes, such as innate immunity [2], the cell cycle [3], hippocampal neurogenesis [4].
作者
刘子超
黄奕乐
刘兴国
Zichao Liu;Yile Huang;Xingguo Liu(CAS Key Laboratory of Regenerative Biology,Joint School of Life Sciences,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou Medical University,Guangzhou 510530,China;Centre for Regenerative Medicine and Health,Hong Kong Institute of Science&Innovation,Chinese Academy of Sciences,Hong Kong 999077,China;Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine,China-New Zealand Joint Laboratory on Biomedicine and Health,CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine,GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre,Institute for Stem Cell and Regeneration,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou 510530,China;University of Chinese Academy of Sciences,Beijing 100049,China)
基金
supported by the National Key Research and Development Program of China (2023YFE0210100, 2022YFE0210100, 2019YFA0904500, 2022YFA1103800)
the National Natural Science Foundation of China (32025010, 92157202, 32241002, 92254301, 92357302, 32261160376,31970709, 32070729, 32100619, 32170747, 32322022, 32370782, 32371007, 32300608, 32300620)
NSFC/RGC Joint Grant Scheme 2022/2023 (N_CUHK 428/22)
the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB0480000)
the Key Research Program, CAS (ZDBSZRKJZ-TLC003)
International Cooperation Program, CAS (154144KYSB20200006)
CAS Project for Young Scientists in Basic Research (YSBR-075)
Guangdong Province Science and Technology Program (2023B0303000023, 2023B1111050005, 2023A1515030231, 2022A1515110493, 2023B1212060050, 2021A1515012513, 2021B1515020096, 2022A1515012616, 2022A1515110951, 2023B1212120009)
Guangzhou Science and Technology Program (202102021037, 202102020827, 202102080066, 202206060002, 2023A04J0414)
Health@Inno HK funding support from the Innovation Technology Commission of the Hong Kong SAR, Basic Research Project of Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and CAS Youth Innovation Promotion Association。
