基于专利视角的附子炮制减毒方法现状分析与评述

Analysis and review of current situation of Aconiti Lateralis Radix Praeparata attenuating methods based on patent perspective

附子Aconiti Lateralis Radix Praeparata作为常见的有毒中药,其炮制减毒工艺一直备受重视。随着科技进步,新型炮制减毒方法不断涌现。通过Incopat全球专利数据库,采用专利分析方法与SWOT分析方法,对附子及乌头的炮制减毒方法进行专利导航分析。结果表明,全球多个国家均有附子减毒相关专利申请,其中我国专利数量远超其他国家。技术构成分析结果表明,水煎、蒸制、炒制等传统减毒方法仍是主流,结构转化、发酵和微波等新方法是近年来附子减毒的重点研究方向,极具发展前景。但这些新方法的专利转化率较低,多数研究还停留在基础研究阶段,亟待完成产业化开发。因此,建议加大“政、产、学、研、用”间的协作力度,提升创新成果转化力,促进附子炮制减毒专利的转化与应用。

Fuzi(Aconiti Lateralis Radix Praeparata)is a common toxic Chinese medicine,whose processing and attenuating technology of aconite has been paid much attention.With the advancement of science and technology,new methods of preparation and reduction of toxicity are constantly emerging.Based on Incopat global patent database,patent analysis method and SWOT analysis method were used to conduct patent navigation analysis of processing attenuating methods of Aconiti Lateralis Radix Praeparata and aconite.The results showed that there were patent applications related to the attenuation of Aconiti Lateralis Radix Praeparata in many countries in the world,and the number of patents in China was far more than other countries,which is the main advantage country.The results of technical composition analysis showed that traditional methods such as decocting,steaming and stir-frying still accounted for the mainstream,while structural transformation,fermentation and microwave were the emerging methods and key research directions for toxification reduction of Aconiti Lateralis Radix Praeparata in recent years,which had great development prospects.However,the patent conversion rate of these new methods is low,and most of the research is still in the basic research stage,which is in urgent need of completing industrialization and development.Therefore,it is suggested to increase the cooperation between“government,industry,education,research and application”,enhance the transformation of innovation achievements,and promote the transformation and application of Aconiti Lateralis Radix Praeparata processing attenuated patents.