基于文献计量学的中药抗血栓研究热点与趋势分析

Analysis of research hotspot and trend in traditional Chinese medicine for antithrombotic effect based on bibliometrics

目的基于文献计量学分析中药抗血栓研究领域的研究热点和发展趋势。方法检索中国知网数据库(China National Knowledge Infrastructure,CNKI)与Web of Science(WOS)核心合集,2000年1月1日—2023年5月23日收录的中药抗血栓相关文献。应用CiteSpace 6.2 R2软件对作者、机构、关键词进行分析,绘制可视化图谱。采用Excel 2019汇总文献发布时间、期刊、研究类型、疾病等信息,分析和总结中药抗血栓领域临床研究和基础研究的趋势和进展。结果纳入867篇文献,其中291篇基础研究,140篇临床研究,其他还包括综述、数据挖掘和网络药理学相关文献。中药抗血栓临床研究领域涉及缺血性脑卒中、深静脉血栓、急性冠脉综合征等16种疾病;血塞通胶囊、脑心通胶囊、冠心宁片等是研究较多的中成药。基础研究文献分析显示,中药通过抗血小板、抗凝、促纤溶、改善内皮功能等途径抑制血栓形成。关键词共现分析发现,中药与西医抗栓药物之间的相互作用是研究热点。结论大量临床与基础研究证明中药具有抗血栓作用。深入探索中药与西医抗血栓药之间相互作用的机制,明确中西医结合抗血栓治疗优势是未来的研究趋势。

Objective To analyze the research hotspot and trend in the field of traditional Chinese medicine(TCM)for antithrombotic activity based on bibliometrics.Methods The related articles published January 1,2000 to May 23,2023 were retrieved from the Web of Science Core Collection database and CNKI database.CiteSpace 6.2R2 software was used to conduct collaborative network analysis of authors,institutions,and keywords.Excel 2019 was used to analyze the analyze the publication year,study type,related disease.Results A total of 867 articles were included in this bibliometric analysis,including 291 basic studies and 140 clinical studies,others include reviews,data mining,and network pharmacology related literature.Clinical research field involves 16 diseases such as ischemic stroke,deep vein thrombosis and acute coronary syndrome.Xuesaitong Capsules(血塞通胶囊),Naoxintong Capsules(脑心通胶囊)and Guanxinning Tablets(冠心宁片)are popular Chinese patent medicine.The results of basic research literature analysis showed that the TCM could inhibit thrombosis by antiplatelet,anticoagulation,promoting fibrinolysis and improving endothelial function.The interaction between TCM and modern antithrombotic drugs was the focus of attention in the future.Conclusion Many clinical and basic studies have proved that the antithrombotic effect of TCM.It is a future research trend to explore the mechanism of interaction between TCM and western medicine and clarify the advantages of integrated Chinese and western medicine in anti-thrombotic treatment.