唾液酸结合免疫球蛋白样凝集素-15在食管鳞癌组织中的表达及意义

Expression and significance of sialic acid-binding immunoglobulin-like lectin-15 in esophageal squamous cell carcinoma

目的探讨免疫检查点唾液酸结合免疫球蛋白样凝集素-15(Siglec-15)在食管鳞癌中的表达及意义。方法免疫组化检测食管鳞癌组织、癌旁正常食管组织中Siglec-15表达情况,并比较分析其与食管鳞癌患者临床病理特征的关系。结果Siglec-15在食管鳞癌组织中表达阳性率为60.0%(48/80),高于癌旁正常食管组织中的23.75%(19/80)(χ^(2)=21.595,P<0.001)。食管鳞癌组织中Siglec-15蛋白表达与患者肿瘤直径、T分期、TNM分期、N分期及分化程度有关(χ^(2)=7.500,P=0.006;χ^(2)=10.342,P=0.001;χ^(2)=22.547,P=0.016;χ^(2)=20.508,P<0.001;χ^(2)=12.586,P=0.002)。结论Siglec-15在食管鳞癌组织中高表达,与患者的疾病进展显著相关。

Objective To investigate the expression and significance of immune checkpoint sialic acid-binding immunoglobulin-like lectin-15(Siglec-15)in esophageal squamous cell carcinoma.Methods Immunohistochemical method was used to detect Siglec-15 expression in esophageal cancer tissue and adjacent tissue,and the relationship between Siglec-15 and clinicopathologic characteristics of esophageal squamous cell carcinoma.Results The Siglec-15 protein positive in esophageal squamous cell carcinoma tissues[60.0%(48/80)]was higher than that in normal esophageal tissues adjacent to the cancer[23.75%(19/80);χ^(2)=21.595,P<0.001].There were statistical differences between Siglec-15 protein positivity and tumour diameter,T stage,TNM stage,N stage and degree of differentiation under different pathologies of esophageal squamous cell carcinoma(χ^(2)=7.500,P=0.006;χ^(2)=10.342,P=0.001;χ^(2)=22.547,P=0.016;χ^(2)=20.508,P<0.001;χ^(2)=12.586,P=0.002).Conclusion Siglec-15 is highly expressed in esophageal squamous cell carcinoma,and is related with disease progression.