设置外部对照的单臂试验偏倚控制方法研究进展分析

Analysis of Research Progress on Bias Control Methods for Single-Arm Trials with External Controls

目前,单臂试验设置外部对照的方法学研究仍处于发展阶段,面临数据存在样本异质性、偏倚识别及其校正方法不完善等挑战。本文系统检索设置外部对照的单臂试验偏倚控制相关文献,并提取有关信息,总结了研究过程中控制偏倚的策略措施,为相关研究者在单臂试验设置外部对照及控制偏倚方面提供方法学参考。

Methodological studies on external control for single-arm trials are still evolving,facing challenges such as sample heterogeneity and imperfect methods for bias identification and correction.This paper systematically reviews literature related to bias control in single-arm trials with external controls,and summarizes strategies for controlling bias in the research process.It aims to provide methodological guidance for researchers in establishing external controls and minimizing bias in single-arm trials.