基于CiteSpace的仙灵骨葆临床研究可视化分析

A CiteSpace-based visualization analysis of clinical research on Xianling Gubao(仙灵骨葆)

目的:通过CiteSpace可视化分析探究仙灵骨葆的临床研究现状与发展趋势。方法:应用计算机在中国知网中检索关于仙灵骨葆的临床研究文献,检索年限为1991—2023年。根据文献纳入标准和排除标准筛选文献,将引文数据导入CiteSpace软件,对年发文量、作者、机构、关键词等进行可视化分析。结果:①一般结果。检索获得文献848篇,最终纳入文献624篇,发表在233种期刊上,涉及作者1692位、机构776家。②年发文量。1999—2005年,年发文量均在10篇以下,且波动不大;2006—2008年,年发文量呈快速上升趋势;2009—2013年,年发文量维持在20~30篇,呈小幅波动趋势;2014—2017年,年发文量逐步增加,并在2017年达到峰值;2018—2023年,年发文量呈波动性下降趋势。③作者。发文量较大的作者合作网络分别是以史晓林为核心的合作网络和包括史历、侯钦午、马俊岭等的合作网络。④机构。发文量位于前5的机构依次为浙江省丽水市中心医院、广州中医药大学第一附属医院、上海市浦东新区北蔡社区卫生服务中心、浙江中医药大学第二附属医院、中国中医科学院中医临床基础医学研究所。⑤关键词。共现网络分析结果显示,突出节点有仙灵骨葆、骨质疏松、骨密度、临床观察、临床疗效等;频次分析结果显示,仙灵骨葆、骨质疏松、骨密度、临床观察出现频次较高;聚类分析结果显示,仙灵骨葆、骨质疏松、骨折、骨密度聚类规模较大;突现分析结果显示,2005年前的突现词为临床观察、中药治疗、骨复活汤,2006—2008年的突现词为临床研究、膝关节、骨关节炎等,2009—2017年的突现词为玻璃酸钠、骨折愈合、钙尔奇D等,2018年后的突现词为骨代谢、生活质量、甲氨蝶呤等。结论:仙灵骨葆的临床研究整体上处于稳定发展中,出现了阶段性的上升和下降;研究团队较少,作者较为分散,团队之间合作不紧密;研究机构分布广泛,机构之间合作不紧密;仙灵骨葆治疗骨质疏松的关注度较高;探究仙灵骨葆影响骨代谢的作用机制可能是下一阶段的研究方向。

Objective:To explore the clinical research status and trends of Xianling Gubao(仙灵骨葆,XLGB)through a CiteSpace-based visual analysis.Methods:The clinical research articles about XLGB included from 1991 to 2023 were retrieved from China National Knowledge Infrastructure through computer.The articles were screened according to the inclusion and exclusion criteria,and then the data from the included articles were imported into the CiteSpace software for visually analyzing the annual number of publications,authors,institutions,and keywords.Results:①Eight hundred and forty-eight articles were searched out.After screening,624 ones were included in the final analysis,involving 233 journals,1692 authors,and 776 institutions.②The annual number of publications was below 10 with slight fluctuations from 1999 to 2005,surged from 2006 to 2008,remained at 20-30 with slight fluctuations from 2009 to 2013,gradually increased from 2014 to 2017 and peaked in 2017,and declined with fluctuations from 2018 to 2023.③The author collaboration networks with a large number of publications were that centered around SHI Xiaolin and that including SHI Li,HOU Qinwu,and MA Junling.④The top 5 institutions with the largest number of publications were Lishui Central Hospital of Zhejiang Province,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Beicai Community Health Service Center in Pudong New Area of Shanghai,The Second Affiliated Hospital of Zhejiang Chinese Medical University,and Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences in turn.⑤The result of keyword co-occurrence network(KCN)analysis showed that the salient nodes included XLGB,osteoporosis(OP),bone mineral density(BMD),clinical observation,and clinical efficacy.The result of frequency analysis showed that XLGB,OP,BMD and clinical observation appeared more frequently.The cluster analysis revealed large clusters on XLGB,OP,fractures,and BMD.Furthermore,the keyword burst analysis indicated that the burst keywords were clinical observation,Chinese medicine treatment,and Gufuhuo Tang(骨复活汤)before 2005;clinical research,knee joint,and osteoarthritis during 2006-2008;sodium hyaluronate,fracture healing,and calcium carbonate and vitamin D3 tablets during 2009-2017;and bone metabolism,quality of life,and methotrexate after 2018.Conclusion:The clinical research on XLGB exhibits steady development in general,with phased rises and declines;meanwhile,less research teams are concerned on XLGB,with scattered authors and loose collaboration between teams;besides,the related research institutions are wide-spreading with loose collaboration.XLGB has attracted more attention in treatment of OP,and its mechanism(s)involved in regulating bone metabolism may be a future research orientation.