右旋布洛芬栓佐治儿童重症手足口病的临床效果

Clinical effect of Dexibuprofen Suppositories in the treatment of children with severe hand foot mouth disease

目的探讨右旋布洛芬栓佐治儿童重症手足口病的临床效果。方法选取川北医学院附属医院急诊科2017年4月至2021年10月收治的96例重症手足口病患儿作为研究对象,采用随机数字表法分为对照组(48例)与观察组(48例)。对照组给予常规治疗,观察组在对照组基础上给予右旋布洛芬栓治疗。比较两组临床疗效、临床症状消失时间、炎症因子水平、心肌损伤情况及不良反应发生情况。结果观察组总有效率为95.83%(46/48),高于对照组的87.50%(42/48),差异有统计学意义(P<0.05)。观察组发热、疱疹、口腔溃疡消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,观察组肿瘤坏死因子-α、白介素-6、C反应蛋白水平均低于对照组,差异有统计学意义(P<0.05)。观察组肌酸激酶、乳酸脱氢酶水平均低于对照组,差异有统计学意义(P<0.05)。对照组不良反应总发生率为2.08%(1/48),观察组不良反应总发生率为4.17%(2/48),两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论采用右旋布洛芬栓佐治儿童重症手足口病可提高临床疗效,缩短临床症状消失时间,降低炎症因子水平,改善心肌损伤情况,且不增加不良反应,值得推广。

Objective To explore the clinical effect of Dexibuprofen Suppositories in the treatment of children with severe hand foot mouth disease(HFMD).Methods A total of 96 children with severe HFMD admitted to Affiliated Hospital of North Sichuan Medical College from April 2017 to October 2021 were selected as the study objects.All the children were divided into the control group(48 cases)and the observation group(48 cases)using the random number table method.The control group received routine treatment,and the observation group received the treatment with Dexibuprofen Suppositories on the basis of the control group.The clinical efficacy,disappearance time of clinical symptoms,levels of inflammatory factors,myocardial injury,and incidence of adverse reactions of the two groups were compared.Results The total effective rate of the observation group was 95.83%(46/48),which was higher than 87.50%(42/48)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of fever,herpes,and oral ulcer in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α,interleukin-6,and C-reactive protein in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of creatine kinase and lactate dehydrogenase in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the control group was 2.08%(1/48),while that was 4.17%(2/48)in the observation group.There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of Dexibuprofen Suppositories in the treatment of children with severe HFMD can improve clinical efficacy,shorten the disappearance time of clinical symptoms,reduce the levels of inflammatory factors,improve the myocardial injury,and does not increase adverse reactions,which is worth promoting.