基于数据挖掘常亚霖对治疗乳腺增生用药规律的研究

Research on medication patterns for treating breast hyperplasia based on data mining

目的运用数据挖掘技术,对常亚霖门诊治疗乳腺增生患者的处方进行分析研究,探索并归纳出其治疗乳腺增生的用药规律,为临床治疗乳腺增生提供参考和辨证用药思路。方法收集2017年1月1日至2022年12月31日在酒泉市中医院常亚霖门诊治疗乳腺增生患者处方,经归纳整理后建立数据资料表,使用Excel2019对药物频次及性味归经进行统计分析,采用SPSSModoler18.0软件Aprior算法对药物进行关联规则分析,运用SPSSStatistics进行聚类分析。结果共纳入处方184首,涵盖中药140种,使用总频次4059次,其中山萸肉、干姜、炙甘草、茯苓、大枣等为治疗乳腺增生的常用药,使用较多的前3类中药分别为补虚药、温里药、解表药。药性以温、平为主;药味以甘、辛、苦为最;药物归经以脾、肺、心经为主。关联规则分析得出炙甘草-白芍、茯苓、甘草以及山萸肉-白芍、大枣、干姜药对等。以欧式距离聚类,将常用药物分为4类。结论常亚霖治疗乳腺增生以肝脾同调、攻补兼施、痰瘀同治的核心思想贯彻始终,在组方潜药上以益气健脾药、补阴/血调肝药配伍化瘀/化痰散结药为主,针对“冷痰”、“瘀毒”又善用十八反、十九畏等相反相成之配伍,其理法方药较具特色,值得进一步研究推广。

Objective To analyze and study the prescriptions of Chief Physician Chang Yalin for treating breast hyperplasia patients in the outpatient department,explores and summarizes the medication patterns for treating breast hyperplasia,and provides reference and dialectical medication ideas for clinical treatment of breast hyperplasia by using data mining technology.Methods Collect the prescriptions of Dr.Chang Yalin for treating breast hyperplasia patients at the Outpatient Department of Jiuquan Traditional Chinese Medicine Hospital from January 1,2017 to December 31,2022.After induction and organization,establish a data table,use Excel 2019 to statistically analyze the drug frequency and gender,taste,and meridian.Use SPSS Modoler 18.0 software April algorithm to analyze the association rules of the drugs,and use SPSS Statistics for cluster analysis.Results A total of 184 prescriptions were included,covering 140 types of traditional Chinese medicine,with a total frequency of use of 4059 times.Among them,Cornus officinalis,dried ginger,roasted licorice,Poria cocos,and jujube are commonly used drugs for the treatment of breast hyperplasia.The top three types of Chinese medicine that are commonly used are tonifying deficiency,warming internal medicine,and relieving external symptoms.The medicinal properties are mainly warm and mild;The medicinal taste is characterized by sweetness,bitterness,and bitterness;The main meridians of drugs are spleen,lung,and heart meridians.Association rule analysis shows that roasted licorice white peony,poria cocos,licorice,and cornus flesh white peony,jujube,and ginger are equivalent.Classify commonly used drugs into 4 categories using Euclidean distance clustering and segmentation with 5.Conclusion Dr.Chang Yalin has always implemented the core idea of treating breast hyperplasia through the coordination of liver and spleen,the simultaneous application of attack and tonifying,and the simultaneous treatment of phlegm and blood stasis.In terms of the combination of latent drugs,the main focus is on tonifying qi and spleen,tonifying yin/blood and regulating liver,and resolving stasis/resolving phlegm and dispersing stagnation.In terms of the combination of“cold phlegm”and“blood stasis and toxin”,as well as the combination of“eighteen contraindications”and“nineteen contraindications”,his principles and methods are more distinctive and worthy of further research and promotion.