血清BDNF、VitB_(12)、Tau蛋白水平与缺氧缺血性脑病早产儿脑神经发育的相关性分析

Correlation analysis of serum BDNF,VitB_(12) and Tau protein levels with brain nerve development in premature infants with hypoxic-ischemic encephalopathy

目的探究血清脑源性神经营养因子(BDNF)、维生素B_(12)(VitB_(12))、Tau蛋白水平与缺氧缺血性脑病早产儿脑神经发育的相关性。方法选取2020年1月至2023年6月收治的80例缺氧缺血性脑病早产儿作为患儿组,另选取同期80例健康新生儿作为健康组。检测新生儿血清BDNF、VitB_(12)、Tau蛋白水平,评估新生儿神经行为评定法(NBNA)评分,分析血清BDNF、VitB_(12)、Tau蛋白水平与NBNA评分的相关性。结果出生后3 d,患儿组的BDNF、VitB_(12)水平及NBNA评分低于健康组,Tau蛋白水平高于健康组,差异具有统计学意义(P<0.05)。CT检查结果显示,轻度组33例,中度组35例,重度组12例;出生后3 d,不同疾病程度患儿的BDNF、VitB_(12)、Tau蛋白水平及NBNA评分比较,差异具有统计学意义(P<0.05)。患儿组出生后14 d的BDNF、VitB_(12)水平及NBNA评分高于出生后3 d,Tau蛋白水平低于出生后3 d,差异具有统计学意义(P<0.05)。Pearson相关性分析结果显示,BDNF、VitB_(12)水平与NBNA评分呈正相关(r=0.473、0.435,P<0.05);Tau蛋白水平与NBNA评分呈负相关(r=-0.411,P<0.05)。结论血清BDNF、VitB_(12)水平与缺氧缺血性脑病早产儿脑神经发育呈正相关,Tau蛋白水平与缺氧缺血性脑病早产儿脑神经发育呈负相关。

Objective To investigate the correlation between serum brain-derived neurotrophic factor(BDNF),vitamin B_(12)(VitB_(12)),Tau protein levels with brain nerve development in premature infants with hypoxic-ischemic encephalopathy.Methods A total of 80 premature infants with hypoxic-ischemic encephalopathy admitted from January 2020 to June 2023 were selected as the sickchildren group,and 80 healthy newborns in the same period were selected as the healthy group.The levels of serum BDNF,VitB_(12) and Tau protein in neonates were detected,and the Neonatal Behavioral Neurological Assessment(NBNA)score was evaluated.The correlation between serum BDNF,VitB_(12),Tau protein levels and NBNA score were analyzed.Results At 3 d after birth,the levels of BDNF,VitB_(12) and NBNA score in the sickchildren group were lower than those in the healthy group,the level of Tau protein was higher than that in the healthy group,and the differences were statistically significant(P<0.05).The results of CT examination showed that there were 33 cases in the mild group,35 cases in the moderate group and 12 cases in the severe group;at 3 d after birth,there were statistically significant differences in BDNF,VitB_(12),Tau protein levels and NBNA score among children with different degrees of disease(P<0.05).The levels of BDNF,VitB_(12) and NBNA score at 14 d after birth were higher than those at 3 d after birth,the level of Tau protein was lower than that at 3 d after birth,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the levels of BDNF and VitB_(12) were positively correlated with NBNA score(r=0.473,0.435,P<0.05);Tau protein level was negatively correlated with NBNA score(r=-0.411,P<0.05).Conclusion The levels of serum BDNF and VitB_(12) are positively correlated with the development of brain nerve in premature infants with hypoxic-ischemic encephalopathy,and the level of Tau protein is negatively correlated with the development of brain nerve in premature infants with hypoxic-ischemic encephalopathy.