甲状腺激素水平检测在妊娠早期的临床价值

The clinical value of thyroid hormone level detection in early pregnancy

目的 探讨甲状腺激素水平检测在妊娠早期的临床价值,为临床早期干预及改善妊娠结局提供参考依据。方法 选取本院进行健康产检的40例妊娠早期孕妇为试验组,同期健康体检的40例非妊娠育龄期女性为对照组,两组均接受甲状腺激素水平检测,并对其检测结果进行比较。结果 试验组促甲状腺素水平低于对照组,三碘甲状腺原氨酸、甲状腺素、游离三碘甲腺原氨酸水平高于对照组(P<0.05)。与甲状腺功能正常组相比,甲状腺功能亢进组三碘甲状腺原氨酸、甲状腺素、游离三碘甲腺原氨酸、游离甲状腺素水平升高,促甲状腺素水平降低;甲状腺功能减退组三碘甲状腺原氨酸、甲状腺素、游离三碘甲腺原氨酸、游离甲状腺素水平降低,促甲状腺素水平升高(P<0.05)。甲状腺功能减退组不良妊娠结局发生率高于甲状腺功能正常组、甲状腺功能亢进组(P<0.05)。结论 对妊娠早期孕妇实施甲状腺激素水平检测,能够实现对孕妇甲状腺功能的监测,辅助临床对甲状腺异常疾病进行判断,对预防孕妇不良妊娠结局具有重要积极影响。

Objective To explore the clinical value of thyroid hormone level detection in early pregnancy,providing reference for early clinical intervention and improving pregnancy outcomes.Methods 40 pregnant women in early pregnancy who underwent healthy prenatal examinations in our hospital were selected as the experimental group,and forty non pregnant women of childbearing age who underwent health examinations during the same period were selected as the control group.Both groups received thyroid hormone level testing and their test results were compared.Results The levels of thyrotropin in the experimental group were lower than those in the control group,while the levels of triiodothyronine,thyroxine,and free triiodothyronine were higher than those in the control group(P<0.05).Compared with the group with normal thyroid function,the group with hyperthyroidism had higher levels of triiodothyronine,thyroxine,free triiodothyronine,and free thyroxine,while the level of thyrotropin decreased;The levels of triiodothyronine,thyroxine,free triiodothyronine,and free thyroxine decreased in the hypothyroidism group,while the levels of thyrotropin increased(P<0.05).The incidence of adverse pregnancy outcomes in the hypothyroidism group was higher than that in the normal thyroid function group and hyperthyroidism group(P<0.05).Conclusion The implementation of thyroid hormone level testing in early pregnancy can achieve monitoring of thyroid function in pregnant women,assist clinical diagnosis of thyroid abnormalities,and have an important positive impact on preventing adverse pregnancy outcomes in pregnant women.