广州社区中老年人群肥胖、身体活动与血清肝功能指标的相关性研究

Correlation of obesity and physical activity with serum liver function indicators in middle-aged and elderly population in Guangzhou

目的分析广州社区中老年人群肥胖、身体活动与血清肝功能指标的关联。方法基于广州生物库队列研究数据,采用多元线性回归模型分析中心性肥胖、全身性肥胖和身体活动与血清肝功能指标的关联性。通过加入交互作用项评估肥胖与身体活动的交互作用对肝功能指标的影响。结果纳入了8714名参与者,平均年龄(64.65±6.05)岁。女性6251人(71.74%),男性2463人(28.26%)。相对非中心性肥胖组,中心性肥胖具有高谷丙转氨酶(ALT)和谷草转氨酶(AST)水平以及低白蛋白(ALB)水平,回归系数β分别为4.74、0.66、-0.27 IU/L(均P<0.01)。相对非全身性肥胖组,全身性肥胖具有高ALT和AST水平以及低ALB水平,回归系数β分别为5.72、1.23、-0.36 IU/L(均P<0.01)。相对身体活动活跃组,非活跃组的AST水平较高,回归系数β为0.53 IU/L(P<0.01)。结论中心性肥胖、全身性肥胖及低身体活动水平与血清肝功能指标异常存在显著关联,提示肥胖管理、增加体力活动对于维持肝功能水平的重要性。

Objective To analyze the correlation of obesity and physical activity with serum liver function indicators in the middle-aged and elderly population in Guangzhou.Methods Based on the data of Guangzhou Biobank Cohort Study,multiple linear regression model was used to analyze the correlation of central obesity,systemic obesity,and physical activity with various serum liver function indicators.The effects of the interaction between obesity and physical activity on liver function indicators were evaluated by adding interaction terms.Results A total of 8714 participants with a mean age of(64.65±6.05)years were included.There were 6251 females(71.74%)and 2463 males(28.26%).Compared with the non-central obesity group,the central obesity group had higher alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels,and lower albumin(ALB)levels,and the regression coefficientsβwere 4.74,0.66,and-0.27 IU/L,respectively(all P<0.01).Compared with the non-systemic obesity group,the systemic obesity group had higher ALT and AST levels and lower ALB levels,and the regression coefficientsβwere 5.72,1.23,and-0.36 IU/L,respectively(all P<0.01).AST levels in inactive group were higher than those in active group,and the regression coefficientβwas 0.53 IU/L(P<0.01).Conclusion Central obesity,systemic obesity,and low physical activity level were significantly correlated with abnormal serum liver function indicators,suggesting the importance of obesity management and increasing physical activity in maintaining liver function.