扶阳通络法联合前列地尔、血塞通治疗动脉硬化闭塞症的临床疗效

The Effect of Fuyang Tongluo Method Combined with Alprostadil and Xuesaitong in the treatment of Arteriosclerosis Obliterans

目的:探讨扶阳通络法联合前列地尔、血塞通治疗动脉硬化闭塞症的效果及对踝肱指数(ABI)和凝血功能的影响。方法:选取北京中医药大学东直门医院洛阳医院2020年8月到2023年8月收治的90例动脉硬化闭塞症患者,应用随机数字表法将患者分为观察组与对照组,各45例。对照组采取前列地尔+血塞通治疗,观察组采取扶阳通络法+前列地尔+血塞通治疗。比较两组患者临床治疗效果,治疗前后中医证候积分、ABI、纤维蛋白原(FIB)、血脂水平以及血管内皮功能相关指标变化。结果:观察组患者治疗总有效率明显高于对照组,差异具有统计学意义(P<0.05);治疗后两组患者溃疡、跛行、疼痛、麻木、凉感相关中医证候积分降低,且观察组低于对照组,差异具有统计学意义(P<0.05);治疗后观察组患者ABI高于对照组,FIB水平低与对照组,差异具有统计学意义(P<0.05);治疗后观察组患者血清总胆固醇(TC)、甘油三酯(TG)水平均低于对照组,差异具有统计学意义(P<0.05);治疗后观察组患者血清一氧化氮(NO)水平高于对照组,血清内皮素–1(ET–1)水平低于对照组,差异具有统计学意义(P<0.05)。结论:扶阳通络法联合前列地尔、血塞通治疗动脉硬化闭塞症疗效显著,可改善患者临床症状,提高ABI与改善凝血功能,降低机体血脂水平,改善血管内皮功能。

Objective To evaluate the effect of Fuyang Tongluo method combined with alprostadil and Xuesaitong in the treatment of atherosclerosis obliterans and its effect on ankle brachial index(ABI)and coagulation function.Methods Ninety patients admitted to Luoyang Branch of Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine from August 2020 to August 2023 were selected.The patients were randomly divided into an observation group and a control group using a random numbeRtable method,with 45 cases in each group.The control group received treatment with alprostadil and Xuesaitong,while the observation group received treatment with Fuyang Tongluo method,alprostadil and Xuesaitong.The clinical treatment effects,and the traditional Chinese medicine(TCM)syndrome scores,ABI,fibrinogen(FIB),blood lipid levels,and vasculaRendothelial function related indicators before and afteRtreatment were compared.Results The total effective rate of treatment in the observation group was significantly higherthan that in the control group,and the difference was statistically significant(P<0.05).Aftertreatment,the TCM syndrome scores related to ulcers,claudication,pain,numbness,and coolness decreased in both groups of patients,and the TCM syndrome scores of the observation group were lowerthan those of the control group,with statistical significances(P<0.05).The ABI of the observation group patients was higherthan that of the control group,and the FIB level was lowerthan that of the control group,with statistical significances(P<0.05).Aftertreatment,the levels of serum total cholesterol(TC)and serum triglyceride(TG)in the observation group were lowerthan those in the control group,and the differences were statistically significant(P<0.05).The level of serum nitric oxide(NO)in the observation group was higherthan that in the control group,and the level of serum endothelin-1(ET-1)was lower than that in the control group,with statistical significances(P<0.05).Conclusion The curative effect of Fuyang Tongluo method combined with alprostadil and Xuesaitong is remarkable,which can improve the clinical symptoms of patients,improve ABI and coagulation function,reduce the blood lipid levels,and improve vasculaRendothelial function.