温针灸联合复方雪莲胶囊治疗强直性脊柱炎对软骨代谢和炎性反应的影响

Effect of Warm Acupuncture and Moxibustion Combined with Compound Xuelian Capsules on the Cartilage Metabolism and Inflammatory Reaction in the Treatment of Ankylosing Spondylitis

目的探讨温针灸联合复方雪莲胶囊治疗强直性脊柱炎对软骨代谢和炎性反应的影响。方法选取医院2020年6月至2022年6月收治的强直性脊柱炎患者178例,按治疗方案的不同分为对照组和观察组,各89例。两组患者均予温针灸治疗,观察组患者加服复方雪莲胶囊。两组均连续治疗2个月。结果观察组总有效率为95.51%,显著高于对照组的85.39%(P<0.05)。两组患者治疗后的巴氏强直性脊柱炎疾病活动指数(BASDAI)评分、巴氏强直性脊柱炎功能指数(BASFI)评分、视觉模拟量表(VAS)评分均显著降低,枕墙距、指地距均显著缩小,腰椎活动度均显著改善,血清软骨寡聚基质蛋白、白细胞介素35、肿瘤坏死因子-α、C反应蛋白、白细胞介素2及白细胞介素17的表达水平均显著降低,且观察组改善程度更显著(P<0.05)。观察组患者治疗后的腰背疼痛、关节水肿、关节疼痛、晨僵缓解时间均显著短于对照组(P<0.05)。观察组不良反应发生率为4.49%,显著低于对照组的10.11%(P<0.05)。结论温针灸联合复方雪莲胶囊治疗强直性脊柱炎,能有效缓解患者的临床症状,减轻关节疼痛,抑制炎性反应,降低血清炎性因子表达水平。

Objective To investigate the effect of warm acupuncture and moxibustion combined with Compound Xuelian Capsules on the cartilage metabolism and inflammatory reaction in the treatment of ankylosing spondylitis.Methods A total of 178 patients with ankylosing spondylitis admitted to the hospital from June 2020 to June 2022 were selected and divided into the control group and the observation group based on different treatment regimens,with 89 cases in each group.The patients in the two groups were treated with warm acupuncture and moxibustion,on this basis,the patients in the observation group were treated with Compound Xuelian Capsules orally.Both groups were treated continuously for two months.Results The total effective rate in the observation group was 95.51%,which was significantly higher than 85.39%in the control group(P<0.05).After treatment,the Bath ankylosing spondylitis disease activity index(BASDAI),Bath ankylosing spondylitis functional index(BASFI)and visual analogue scale(VAS)scores in the two groups significantly decreased;the distances of occipital to wall and finger to ground significantly decreased;the lumbar mobility significantly improved;the expression levels of serum cartilage oligomeric matrix protein(COMP),interleukin-35(IL-35),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-2(IL-2)and interleukin-17(IL-17)significantly decreased(P<0.05).The above indexes in the observation group were significantly better than those in the control group(P<0.05).After treatment,the relief time of lower back pain,joint edema,joint pain,and morning stiffness in the observation group was significantly shorter than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 4.49%,which was significantly lower than 10.11%in the control group(P<0.05).Conclusion Warm acupuncture and moxibustion combined with Compound Xuelian Capsules can effectively relieve the clinical symptoms of patients with ankylosing spondylitis,alleviate joint pain,inhibit inflammatory reaction,and decrease the expression level of serum inflammatory factors.