2型糖尿病患者血尿酸水平检验的临床价值分析

Analysis of Clinical Value of Blood Uric Acid Level Tests in Patients with Type 2 Diabetes Mellitus

目的分析2型糖尿病(Type 2 Diabetes Mellitus,T2DM)患者血尿酸(Uric Acid,UA)水平检验的临床价值。方法选取2022年1—12月阜宁县人民医院接受治疗的80例T2DM患者为研究对象,按照不同的UA水平分为高血尿酸组(40例,500μmol/L≤UA<600μmol/L)和低血尿酸组(40例,420μmol/L≤UA<500μmol/L)。另选取同期40名健康体检者(UA<420μmol/L)设为对照组。比较3组UA、血糖指标[随机血糖(Glucose,GLU)、餐后2 h血糖(2-hour Postprandial Plasma Glucose,2 hPG)、糖化血红蛋白(Glycated Hemoglobin A1c,HbA1c)、空腹血糖(Fasting Plasma Glucose,FPG)]、血脂指标[甘油三酯(Triglyceride,TG)、低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)、高密度脂蛋白胆固醇(High Density Lipoprotein Cholesterol,HDL-C)、总胆固醇(Total Cholesterol,TC)]水平及颈动脉内膜-中层厚度(Intimal-medial Thickness,IMT)。并分析UA与血糖、血脂的相关性。结果高血尿酸组各项血糖、血脂水平以及IMT水平高于其余两组,差异有统计学意义(P均<0.05)。UA水平与FPG水平的相关性最强,其次是IMT、HbA1c、2 hPG、GLU、LDL-C、TG、TC、HDL-C,差异有统计学意义(P均<0.05)。结论高血尿酸T2DM患者的血糖、血脂水平更高、IMT更大。UA水平与血糖、血脂具有较高的相关性。

Objective To study and analyze the clinical value of blood uric acid(UA)level test in patients with type 2 diabetes mellitus(T2DM).Methods A total of 80 T2DM patients treated in Funing County People's Hospital from January to December 2022 were selected as the study subjects.According to different blood UA levels,they were di-vided into high blood uric acid group(40 cases,500μmol/L≤UA<600μmol/L)and low blood uric acid group(40 cases,420μmol/L≤UA<500μmol/L).Another 40 healthy subjects(UA<420μmol/L)were selected as control group.The UA,blood glucose index[random blood glucose(GLU),2-hour postprandial plasma glucose(2 hPG),glycated he-moglobin A1c(HbA1c),fasting plasma glucose(FPG)],blood lipid index level[triglyceride(TG),low density lipopro-tein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),total cholesterol(TC)]and carotid artery intima-media thickness(IMT)of the three groups were compared.And the correlation between UA and blood glucose and blood lipid was analyzed.Results The levels of blood glucose,blood lipids and IMT in high blood uric acid group were higher than those in the other two groups,and the differences were statistically significant(all P<0.05).The cor-relation between UA level and FPG level was the highest,followed by IMT,HbA1c,2 hPG,GLU,LDL-C,TG,TC and HDL-C,and the differences were statistically significant(all P<0.05).Conclusion Patients with high blood uric acid T2DM had higher blood glucose and lipid levels and greater IMT.UA levels had a high correlation with blood glucose and lipids.