T2DM合并心肌梗死患者糖代谢控制中阿卡波糖的应用价值

The Application Value of Acarbose in Carbohydrate Metabolism Control in Patients with T2DM Combined with Myocardial Infarction

目的分析2型糖尿病(Type 2 Diabetes Mellitus,T2DM)合并心肌梗死患者糖代谢控制中阿卡波糖的应用效果。方法回顾性选取2022年1月—2023年1月陆军第七十三集团军医院收治的84例T2DM合并心肌梗死患者的临床资料,根据治疗方式的不同分为比照组(n=42,二甲双胍治疗)和观察组(n=42,二甲双胍联合阿卡波糖治疗)。对比两组糖代谢控制情况、临床疗效及不良反应发生率。结果治疗4周后,两组糖代谢水平均低于治疗前,且观察组空腹血糖(6.01±0.21)mmol/L、餐后2 h血糖(7.44±1.12)mmol/L、糖化血红蛋白(6.51±1.14)%均低于比照组,差异有统计学意义(t=2.590、2.159、2.096,P均<0.05)。观察组治疗总有效率(97.62%)高于比照组(85.71%),差异有统计学意义(χ^(2)=3.896,P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论T2DM合并心肌梗死患者糖代谢控制中应用阿卡波糖,糖代谢控制效果更佳,临床疗效显著且具有较高安全性。

Objective To analyze the application effect of acarbose in carbohydrate metabolism control in patients with type 2 diabetes mellitus(T2DM)combined with myocardial infarction.Methods Clinical data of 84 T2DM pa-tients with myocardial infarction admitted to the Army 73rd Group Military Hospital from January 2022 to January 2023 were retrospectively selected,and divided into comparison group(n=42,metformin treatment)and observation group(n=42,metformin combined with acarbose treatment)according to different treatment methods.The control of glucose metabolism,clinical efficacy and incidence of adverse reactions were compared between the two groups.Results After 4 weeks of treatment,glucose metabolism levels in two groups were lower than before treatment,and fasting blood glucose(6.01±0.21)mmol/L,2-hour postprandial blood glucose(7.44±1.12)mmol/L and glycosylated he-moglobin(6.51±1.14)%in observation group were lower than those in comparison group,and the differences were sta-tistically significant(t=2.590,2.159,2.096,all P<0.05).The total effective rate of observation group(97.62%)was higher than that of comparison group(85.71%),and the difference was statistically significant(χ^(2)=3.896,P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of acarbose in the control of carbohydrate metabolism in patients with T2DM combined with myocardial infarction has better glucose metabolism control effect,significant clinical efficacy and high safety.