探究达格列净治疗老年2型糖尿病肾病临床疗效及对肾功能的影响

To Explore the Clinical Efficacy of Daggligin in the Treatment of Senile Type 2 Diabetes Nephropathy and Its Influence on Renal Function

目的分析达格列净治疗治疗老年2型糖尿病肾病临床疗效,以及对患者肾功能造成的影响。方法选择尤溪县中医医院于2022年9月—2023年8月收治的80例老年2型糖尿病肾病患者为研究对象,基于治疗药物的差异性,分为对照组和观察组,均为40例,观察组采用达格列净进行治疗,对照组采用二甲双胍进行治疗。持续3个月治疗后,对比两组疗效(综合肾功能改善结果)、治疗前后血糖水平、不良反应发生情况。结果治疗前,两组患者的空腹血糖和餐后2 h血糖均较高,差异无统计学意义(P均>0.05);治疗后,两组患者的空腹血糖及餐后2 h血糖均有所下降,且观察组均低于对照组,差异有统计学意义(P均<0.05)。观察组的治疗总有效率为97.50%,高于对照组的80.00%,差异有统计学意义(P<0.05)。结论治疗老年2型糖尿病肾病时,达格列净的综合疗效优于二甲双胍,且安全性更高。

Objective To analyze the clinical efficacy of daggligin in the treatment of senile type 2 diabetes nephropa-thy and its impact on renal function.Method Eighty elderly patients with type 2 diabetes nephropathy admitted to Youxi County Hospital of Traditional Chinese Medicine from September 2022 to August 2023 were selected as the study objects and divided into a control group and an observation group based on the difference of treatment drugs,both of which were 40 cases.The observation group was treated with dagglinide,and the control group was treated with metformin.After 3 months of continuous treatment,compare the efficacy(comprehensive improvement of renal function),blood glucose levels before and after treatment,and incidence of adverse reactions between the two groups.Result Before treatment,the fasting blood glucose and 2-hour postprandial blood glucose of the two groups of patients were both higher,and the difference was not statistically significant(both P>0.05);After treatment,the fasting blood glucose and 2-hour postprandial blood glucose of both groups of patients decreased,and the observation group was lower than the control group,and the differences were statistically significant(both P<0.05).The total effective rate of the observation group reached 97.50%,which was higher than the 80.00%of the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of senile type 2 diabetes nephropathy,the comprehen-sive efficacy of daggligin is better than metformin,and the safety is higher.