CysC、Scr、Sur及mAlb联合检验在糖尿病肾病早期诊断中的应用价值

Application Value of CysC,Scr,Sur and MAlb Combined Tests in Early Diagnosis of Diabetic Nephropathy

目的分析胱抑素C(Cystatin C,CysC)、血肌酐(Serum Creatinine,Scr)、血尿素(Serum Urea,Sur)、尿微量白蛋白(Urinary Microalbumin,mAlb)联合诊断糖尿病肾病(Diabetic Nephropathy,DN)的价值。方法选取2021年4月—2023年4月潍坊内分泌与代谢病医院收治的83例DN患者纳入观察组,将同期医院收治的75例单纯糖尿病患者纳入对照组,另将同期于医院体检的85名健康体检者纳入健康组,检测对比3组CysC、Scr、Sur及mAlb差异;另描绘受试者操作特征(Receiver Operating Characteristic,ROC)曲线,分析CysC、Scr、Sur及mAlb诊断DN的价值。结果观察组CysC为(1.35±0.51)mg/L、Scr为(73.58±8.31)μmol/L、Sur为(6.75±1.89)mmol/L、mAlb为(34.21±2.58)mg/L,高于对照组的(0.83±0.26)mg/L、(59.96±5.25)μmol/L、(5.30±1.25)mmol/L、(18.35±2.20)mg/L以及健康组的(0.70±0.14)mg/L、(51.35±4.63)μmol/L、(4.18±0.34)mmol/L、(15.24±1.53)mg/L,且对照组的各项指标高于健康组,差异有统计学意义(P均<0.05)。CysC、Scr、Sur、mAlb联合诊断DN的曲线下面积大于4项指标单独诊断(P<0.05)。结论CysC、Scr、Sur、mAlb能够于早期及时诊断出DN,具有一定的诊断价值。

Objective To analyze the value of cystatin C(CysC),serum creatinine(Scr),serum urea(Sur)and urinary microalbumin(mAlb)in the combined diagnosis of diabetic nephropathy(DN).Methods Eighty-three patients with DN admitted to Weifang Endocrine and Metabolic Disease Hospital from April 2021 to April 2023 were included in the observation group,and seventy-five patients with simple diabetes admitted to hospital during the same period were included in the control group.In addition,eighty-five healthy subjects who underwent physical examination in hospi-tal during the same period were classified into the health group.The differences of CysC,Scr,Sur and mAlb among the three groups were detected and compared.Receiver operating characteristic(ROC)curve was described to analyze the value of CysC,Scr,Sur and mAlb in the diagnosis of DN.Results The CysC,Scr,Sur and mAlb of the observation group were(1.35±0.51)mg/L,(73.58±8.31)μmol/L,(6.75±1.89)mmol/L and(34.21±2.58)mg/L respectively,higher than that of control group(0.83±0.26)mg/L,(59.96±5.25)μmol/L,(5.30±1.25)mmol/L,(18.35±2.20)mg/L,and health group(0.70±0.14)mg/L,(51.35±4.63)μmol/L,(4.18±0.34)mmol/L,(15.24±1.53)mg/L,the indexes of control group were higher than those of health group,and the differences were statistically significant(all P<0.05).The area under the curve(AUC)of the combined diagnosis of DN by CysC,Scr,Sur and mAlb was bigger than that by the four indexes alone(P<0.05).Conclusion CysC,Scr,Sur and mAlb can diagnose DN early and timely,and have certain diagnostic value.