Circle-map profiling of extrachromosomal circular DNA as diagnostic biomarkers for lung cancer

Dear Editor:Lung cancer has the highest incidence rate among malignancies and remains the primary contributor to cancer-related mortality on a global scale[1].Early detection is the most efficacious approach for enhancing the prognosis and mitigating the mortality of patients with lung cancer[2].Currently,diagnosis of lung cancer is mainly by different types of imaging including low-dose spiral computed tomography(LDCT)combined with pathological assessment of biopsy,but prevalence of false-positive results and associated expenses may impede its becoming a standard screening technique[3].