摘要
目的 分析三参通络汤联合阿司匹林及阿托伐他汀钙片在中风急性期气虚血瘀证患者中的治疗效果。方法 选取2021年1月至2023年1月济宁市中医院脑病科收治的88例中风急性期气虚血瘀证患者,按随机数表法分为两组,每组各44例。对照组行阿司匹林、阿托伐他汀钙片治疗,观察组加以三参通络汤治疗,持续用药2周。比较两组临床疗效、中医证候评分、神经功能、血清学相关指标、不良反应。结果 观察组治疗总有效率高于对照组,差异有统计学意义(P <0.05);治疗前,两组各项中医证候评分、美国国立卫生研究院卒中量表(NIHSS)评分及同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)水平比较,差异无统计学意义(P> 0.05);治疗后,两组各项中医证候评分、NIHSS评分与Hcy、hs-CRP水平均低于治疗前,且观察组各项中医证候评分、NIHSS评分与Hcy、hs-CRP水平均低于对照组,差异有统计学意义(P <0.05);两组不良反应总发生率比较,差异无统计学意义(P> 0.05)。结论 三参通络汤联合阿司匹林及阿托伐他汀钙片能够减轻中风急性期气虚血瘀证患者的症状,减轻神经功能损伤,降低Hcy、hs-CRP水平,且无严重不良反应,具有一定的应用价值,值得临床推广应用。
Objective To analyze the efficacy of the combination of Sanshen Tongluo Decoction,aspirin,and atorvastatin calcium tablets in the treatment of acute stroke patients with qi deficiency and blood stasis syndrome.Methods A total of 88 acute stroke patients with qi deficiency and blood stasis syndrome admitted to the Department of Encephalopathy of Jining Traditional Chinese Medicine Hospital from January 2021 to January 2023 were selected and randomly divided into two groups,with 44 patients in each group,using a random number table method.The control group received treatment with aspirin and atorvastatin calcium tablets,while the observation group received additional treatment with Sanshen Tongluo Decoction for 2 weeks.The clinical efficacy,traditional Chinese medicine syndrome scores,neurological functions,serological indicators,and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than the control group,with statistically significant difference(P<0.05).Before treatment,there were no statistically significant differences(P>0.05)between the two groups in various traditional Chinese medicine syndrome scores,national institutes of health stroke scale(NIHSS)scores,and levels of homocysteine(Hcy)and hypersensitive C-reactive protein(hs-CRP),after treatment,the traditional Chinese medicine syndrome scores,NIHSS scores and levels of Hcy and hs-CRP in both groups were lower than those before treatment,and the observation group had significantly lower traditional Chinese medicine syndrome scores,NIHSS scores,Hcy levels,and hs-CRP levels than the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the total of incidence of adverse reations between the two groups(P>0.05).Conclusion The combination of Sanshen Tongluo Decoction,aspirin,and atorvastatin calcium tablets can alleviate the symptoms of acute stroke patients with Qi deficiency and blood stasis syndrome,alleviate neurological damage,and lower Hcy and hs-CRP levels,with no serious adverse reactions.It has a certain application value and is worthy of clinical promotion and application.
作者
阮明军
谢贵娟
马良
RUAN Mingjun;XIE Guijuan;MA Liang(Department of Encephalopathy,Jining Traditional Chinese Medicine Hospital,Shandong,Jining 272000,China;Jining Center For Disease Control and Prevention,Shandong,Jining 272000,China)
出处
《中国医药科学》
2024年第10期144-148,共5页
China Medicine And Pharmacy
基金
山东省中医药科技项目(2020M156)。
关键词
中风
急性期
气虚血瘀证
三参通络汤
阿司匹林
阿托伐他汀钙片
中医证候
Stroke
Acute phase
Qi deficiency and blood stasis syndrome
Sanshen Tongluo Decoction
Aspirin
Atorvastatin calcium tablets
Traditional Chinese medicine syndrome