巨噬细胞在肿瘤免疫治疗中的研究进展

Research Progress of Macrophages in Tumor Immunotherapy

肿瘤相关巨噬细胞(TAMs)可介导血管生成,促进肿瘤侵袭转移,构建免疫抑制微环境。同时,肿瘤微环境中的TAMs水平与疾病预后密切相关。全面了解TAMs作为潜在靶标在免疫治疗中的作用,提高其治疗反应性,尤其是可塑性和异质性,有助于改善治疗效果。近年通过不同策略进行的TAMs靶向治疗已成为临床研究的热点。深入研究TAMs在肿瘤免疫治疗中的作用机制,可以为恶性肿瘤的靶向治疗提供新思路。

Tumor-associated macrophages(TAMs)can mediate angiogenesis,promote tumor invasion and metastasis,and construct immunosuppressive microenvironment.Meanwhile,the level of TAMs in the tumor microenvironment is closely related to the disease prognosis.To fully understand the role of TAMs as potential targets in immunotherapy and improve its therapeutic reactivity,especially plasticity and heterogeneity,is helpful to improve the therapeutic effect.In recent years,TAMs targeted therapy through different strategies has become a hotspot in the clinical research.Further studies of the mechanism of TAMs in tumor immunotherapy can provide new ideas for the targeted therapy of malignant tumors.