巨噬细胞移动抑制因子与代谢综合征相关性的研究进展

Research Progress of Correlation between Macrophage Migration Inhibition Factor and Metabolic Syndrome

代谢综合征(MetS)是一组包括肥胖、高血糖、血脂异常以及高血压等在内的临床代谢紊乱症候群,与糖尿病和心血管疾病风险的增加显著相关,其基本病因及发病机制目前尚未完全阐明。巨噬细胞移动抑制因子(MIF)是一种促炎性细胞因子和免疫活性物质,广泛表达于机体的多个组织细胞,参与多种疾病的发展。MIF通过影响胰岛素抵抗以及慢性炎症的发展在MetS的发生、发展过程中发挥作用。MIF有望成为降低MetS发生风险的潜在炎症干预靶点,进一步明确MIF对MetS的病理作用,对MetS的预防及治疗有重要意义。

Metabolic syndrome(MetS)is a group of clinical metabolic disorders including obesity,hyperglycemia,dyslipidemia and hypertension,which are significantly associated with the increased risks of diabetes and cardiovascular diseases.The basic etiology and pathogenesis have not been fully elucidated.Macrophage migration inhibitory factor(MIF)is a kind of pro-inflammatory cytokine and immunoactive substance,which is widely expressed in many tissues and cells of the body and is involved in the development of many diseases.MIF plays a role in the occurrence and progression of MetS by influencing the development of insulin resistance and chronic inflammation.MIF is expected to become a potential inflammatory intervention target to reduce the risk of MetS,and further clarify the pathological effect of MIF on MetS,which is of great significance for the prevention and treatment of MetS.