塞来昔布联合吲哚美辛栓对预防SAP的价值研究

Value of Celecoxib Combined with Indomethacin Suppository in the Prevention of SAP

目的:探讨塞来昔布联合吲哚美辛栓对预防重症急性胰腺炎(SAP)的价值。方法:选取2021年1月1日—2022年1月1日河南大学第一附属医院急诊科或消化科综合评估确诊为急性胰腺炎(AP)的200例患者作为研究对象,通过抽签随机将其分为常规组101例和实验组99例。常规组患者按最新胰腺炎诊疗指南给药常规治疗,实验组患者在常规治疗基础上给予塞来昔布联合吲哚美辛栓治疗。观测两组患者是否发展为SAP以及有无局部并发症发生,比较两组患者淀粉酶、C反应蛋白(CRP)、血清白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平,并进行多项胰腺炎严重程度评分。结果:实验组患者SAP的发生率及晚期局部并发症发生率均低于常规组患者,实验组患者的淀粉酶、IL-6和TNF-α水平均低于对照组患者,实验组患者的腹痛改善情况优于常规组患者,实验组患者住院时间短于常规组患者,实验组患者总花费少于常规组患者,差异有统计学意义(P<0.05)。结论:塞来昔布联合吲哚美辛栓对预防SAP有效,能够显著降低炎症因子水平,大大降低SAP发生率,明显缩减患者住院成本,缩短住院时间。

Objective:To explore the value of celecoxib combined with indomethacin suppository in the prevention of SAP.Methods:200 patients with AP in the hospital from January 2021 to January 2022 were selected as the study objects,and randomly divided into the conventional group(101 cases)and the experimental group(99 cases).The conventional group was treated with conventional treatment according to the latest guidelines for diagnosis and treatment of pancreatitis.The experimental group was treated with celecoxib on the basis of conventional treatment.Patients of the two groups were observed whether they could develop into SAP and whether there were local complications or not.Amylase,CRP,serum interleukin-6(IL-6)and tumor necrosis factor a(TNF-α)of two groups of patients,and the severity of multiple pancreatitis was scored.Results:Compared with the conventional group,the incidence of SAP in the experimental group was significantly reduced,and the late local complications were significantly reduced.The levels of amylase,IL-6 and TNF-αin the experimental group were significantly lower than those in the control group.The improvement of abdominal pain in the experimental group was more obvious than that in the conventional group.the hospital stays and total cost were significantly reduced,and the difference was statistically significant(P<0.05).Conclusion:Celecoxib combined with indomethacin suppository is effective in preventing SAP.It can significantly reduce the inflammatory factors,greatly decrease SAP rate,and significantly reduce the hospitalization cost,reduce hospitalization time.