基于数据挖掘探析中医药治疗脑梗死处方的用药规律

Analysis on the Medication Law of Traditional Chinese Medicine in the Treatment of Cerebral Infarction Based on Data Mining

目的运用数据挖掘技术探索近10年文献中中医药治疗脑梗死患者的用药规律及其特点。方法通过检索2013年1月1日—2023年1月1日中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)、中国知识网(China National Knowledge Internet,CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(维普网)中医药(含中西医结合)治疗脑梗死的相关文献。完成筛选、建立数据库,在中医传承辅助平台(V3.0)上运用频数统计、聚类分析、关联规则分析等方法,统计药物使用频率、性味归经分布情况,分析药物配伍规律及关联、聚类效果。结果纳入文献共143篇,共整理出161首方剂,222味中药。四气中温(41.51%)、寒(27.55%)、平(25.89%)为主;五味以苦(34.17%)、甘(28.82%)、辛(24.45%)为主;归经以肝(26.68%)、心(17.96%)、脾(16.14%)三经为主;药物频次≥35次的中药共有13味,以活血化瘀类药物为主;药物组合中频次≥45次的有18组;将整理后的222味中药可分为3个聚类。结论脑梗死的治疗药物以温寒平、归心肝经者为多,治疗方法以活血化瘀、补益肝肾、平肝熄风为主,可为临床治疗提供一定借鉴。

Objective To explore the medication patterns and their characteristics of patients with cerebral infarction treated with traditional Chinese medicine(TCM)in the literature in the last 10 years using data mining techniques.Methods By searching the Chinese Biology Medicine disc(CBMdisc),China National Knowledge Internet(CNKI),China Academic Journal Database(Wanfang Data),Chinese Science and Technology Journal Database(Wipo),Chinese Medicine Database(Wanfang Data),and Chinese Journal Database(Wipo)for the period from January 1,2013 to January 1,2023,The stydy found that Chinese medicine was used to treat patients with cerebral infarction.Academic Journal Database(Wanfang Data),Chinese Science and Technology Journal Database(Wipo.com)relevant literature on Chinese medicine(including integrated Chinese and Western medicine)for the treatment of cerebral infarction.After completing the screening and establishing the database,frequency statistics,cluster analysis,association rule analysis and other methods were applied on the Chinese Medicine Inheritance Aid Platform(V3.0)to count the frequency of drug use,the distribution of flavors and attributes,and to analyze the pattern of drug compounding and the effect of association and clustering.Results A total of 143 articles were included,and 161 formulas with 222 flavors of Chinese medicines were compiled;among the four qi,warmth(41.51%),cold(27.55%),and flatness(25.89%)were predominant;among the five flavors,bitterness(34.17%),sweetness(28.82%),and pungency(24.45%)were predominant;and the attributed meridians,liver(26.68%),heart(17.96%),and spleen(16.14%)were predominant.(16.14%)meridians were predominant;a total of 13 traditional Chinese medicines with drug frequency≥35 times were predominantly blood-activating and blood-stasis-removing drugs;there were 18 groups of drug combinations with frequency≥45 times;and the collated 222 traditional Chinese medicines could be classified into 3 clusters.Conclusion The therapeutic drugs for cerebral infarction were mostly warm,cold and flat,and attributed to the heart and liver meridians,and the treatment method was based on activating blood circulation and removing blood stasis,tonifying the liver and kidney,and calming the liver and extinguishing wind,which could provide some reference for clinical treatment.