阿立哌唑与利培酮治疗女性精神分裂症的效果比较

Comparison of Efficacy of Aripiprazole and Risperidone in the Treatment of Female Schizophrenia Patients

目的探讨阿立哌唑和利培酮对于治疗女性精神分裂症患者的疗效。方法选取2022年7月—2023年7月福建省福州神经精神病防治院符合入组条件的85例女性精神分裂症住院患者。随机分为阿立哌唑组和利培酮组,阿立哌唑42例给予阿立哌唑治疗,利培酮组43例给予利培酮治疗。比较2组在治疗前、治疗8周后阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评分、P300成分、血清催乳素水平。结果治疗前,2组PANSS量表评分比较,差异无统计学意义(P>0.05);治疗后,2组PANSS量表评分比较,差异无统计学意义(P>0.05);治疗后,2组PANSS量表评分低于治疗前,差异有统计学意义(P<0.05)。治疗后,2组P300波幅均高于治疗前,差异有统计学意义(P<0.05);2组P300潜伏期与治疗前比较,差异无统计学意义(P>0.05)。治疗前,2组血清催乳素水平比较,差异无统计学意义(P>0.05);治疗后,利培酮组的血清催乳素水平为(37.785±6.068)ng/mL,高于阿立哌唑组的(28.433±5.288)ng/mL与治疗前的(25.522±5.200)ng/mL,差异有统计学意义(P<0.05)。结论阿立哌唑和利培酮作为疗效较好的临床抗精神病药物,能够有效且快速地控制临床精神症状(阴性症状和阳性症状),改善认知功能;阿立哌唑基本不引起血清催乳素水平升高,更适合推荐女性患者服用。

Objective To investigate the efficacy of aripiprazole and risperidone in the treatment of female schizophrenia patients.Methods A total of 85 female hospitalized patients with schizophrenia eligible for enrollment in Fuzhou Neuropsychiatric Prevention and Treatment Hospital,Fujian Province from July 2022 to July 2023 were selected.They were randomly divided into aripiprazole group and risperidone group.42 patients were treated with aripiprazole and 43 patients were treated with risperidone.The positive and negative syndrome scale(PANSS)scores,P300 components and serum prolactin levels were compared between the two groups before treatment and 8 weeks after treatment.Results Before treatment,there was no significant difference in PANSS score between 2 groups(P>0.05).After treatment,there was no significant difference in PANSS score between 2 groups(P>0.05).After treatment,PANSS score of 2 groups was lower than before treatment,and the difference was statistically significant(P<0.05).After treatment,the amplitude of P300 in 2 groups was higher than before treatment,and the difference was statistically significant(P<0.05).There was no significant difference in P300 incubation period between the 2 groups(P>0.05).Before treatment,there was no significant difference in serum prolactin levels between 2 groups(P>0.05).After treatment,the serum prolactin level in risperidone group was(37.785±6.068)ng/mL,which was higher than that in aripiprazole group(28.433±5.288)ng/mL and before treatment(25.522±5.200)ng/mL,and the difference was statistically significant(P<0.05).Conclusion As clinical antipsychotic drugs with good efficacy,aripiprazole and risperidone can effectively and rapidly control clinical psychiatric symptoms(negative and positive symptoms)and improve cognitive function.Aripiprazole basically does not cause an increase in serum prolactin levels,and is more suitable for female patients.