麻蝉止咳汤治疗儿童咳嗽变异性哮喘风寒袭肺证47例临床观察

Clinical observation on the treatment of 47 cases of cough variant asthma with wind cold attacking lung syndrome in children with Machan Zhike Tang(麻蝉止咳汤)

目的观察麻蝉止咳汤治疗儿童咳嗽变异性哮喘(CVA)风寒袭肺证的临床疗效。方法选取2022年9月至2023年3月就诊于黑龙江中医药大学附属第一医院儿一科门诊的CVA风寒袭肺证患儿94例,采用随机数字表法分为对照组和治疗组,各47例。对照组口服孟鲁司特钠咀嚼片治疗,治疗组口服麻蝉止咳汤治疗,2组均连续治疗14 d后统计临床疗效,比较治疗前后咳嗽视觉模拟评分(VAS),莱切斯特咳嗽问卷(LCQ)评分,呼出气一氧化氮(FeNO)以及血清嗜酸性粒细胞(EOS)水平。结果对照组的总有效率为82.98%(39/47),治疗组为87.23%(41/47),2组比较,差异有统计学意义(P<0.05)。治疗前2组咳嗽VAS评分,FeNO计数和血清EOS水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组上述指标值均显著降低,与同组治疗前比较,差异有统计学意义(P<0.01),且治疗组降低更显著(P<0.05)。治疗前2组生理评分、心理评分、社会评分和LCQ总评分比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组上述各评分均显著升高,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组升高更显著(P<0.05)。结论麻蝉止咳汤治疗CVA风寒袭肺证临床疗效确切,不仅可显著改善患儿LCQ评分和咳嗽VAS评分,而且有助于FeNO计数和血清EOS水平的恢复,值得临床推广应用。

ObjectiveeTo observe the clinical efficacy of Machan Zhike Tang(麻蝉止咳汤)in the treatment of wind cold attacking lung syndrome in children with cough variant asthma(CVA).Methods 94 children with CVA wind cold attacking lung syndrome who visited the Pediatric Department of The First Affiliated Hospital of Heilongjiang University of Chinese Medicine from September 2022 to March 2023 were selected.They were randomly divided into a control group and a treatment group,with 47 cases in each group,using a random number table method.The control group received oral treatment with Montelukast sodium chewable tablets,while the treatment group received oral treatment with Machan Zhike Tang.After 14 consecutive days of treatment,the clinical efficacy of both groups was statistically analyzed.The visual analogue scale(VAS)of cough,the Leicester Cough Questionnaire(LCQ)score,exhaled nitric oxide(FeNO),and serum eosinophil(EOS)levels were compared before and after treatment.Results The total effective rate of the control group was 82.98%(39/47),while the total effective rate of the treatment group was 87.23%(41/47).The difference between the two groups was statistically significant(P<O.05).There was no statistically significant difference in cough VAS score,FeNO count,and serum EOS levels between the two groups before treatment(P>0.05),indicating comparability.After treatment,the above indicators in both groups significantly decreased,with a statistically significant difference(P<0.01)compared to before treatment in the same group,and the treatment group showed a more significant decrease(P<0.05).There was no statistically significant dfference(P>0.05)in the physiological score,psychological score,social score,and total LCQ score between the two groups before treatment,indicating comparability.After treatment,the scores of two or more groups significantly increased,and compared with the same group before treatment,the difference was statistically significant(P<0.05),and the treatment group showed a more significant increase(P<0.05).Conclusion The clinical efficacy of Machan Zhike Tang in treating CVA with wind cold attacking lung syndrome is definite.lt can not only significantly improve the LCQ score and cough VAS score of children,but also contribute to the recovery of FeNO count and serum EOS level,which is worthy of clinical promotion and application.