三阳清解液乙状结肠滴注治疗儿童外感发热(风热证)60例临床观察

Clinical observation on the treatment of 60 cases of febrile symptoms(wind heat syndrome)in children with sigmoid colon drip of SanyanggQingjieYe(三阳清解液)

目的观察三阳清解液乙状结肠滴注治疗儿童外感发热(风热证)的临床疗效。方法选取2021年6—12月在河南中医药大学附属郑州市中医院儿科门诊就诊的外感发热(风热证)患儿120例,按照随机数字表法分为对照组和治疗组,各60例。对照组口服小儿柴桂退热颗粒,治疗组给予三阳清解液乙状结肠滴注。2组均治疗2 d,并继续观察24 h后,统计2组的退热起效时间、完全退热时间、治疗期间使用布洛芬的次数、临床疗效及不良反应。结果治疗组的退热起效时间和完全退热时间均较对照组短,2组比较,差异均有统计学意义(P<0.01)。治疗组使用布洛芬的次数少于对照组,2组比较,差异有统计学意义(P<0.01)。对照组总有效率为81.67%(49/60),治疗组为95.00%(57/60),2组总有效率比较,差异有统计学意义(P<0.05)。对照组不良反应发生率为15.00%(9/60),治疗组为8.33%(5/60),2组比较,差异无统计学意义(P>0.05)。2组不良反应均为轻度,均未影响治疗。结论三阳清解液乙状结肠滴注治疗儿童外感发热(风热证),能较快改善儿童发热症状,体温恢复更快,合并使用布洛芬次数少,不良反应小,疗效显著,值得临床推广应用。

Objective To observe the clinical efficacy of Sanyang Qingjie Ye(三阳清解液)in the treatment of children with febrile symptoms(wind heat syndrome)through sigmoid colon drip.Methods 120 children with febrile symptoms(wind heat syndrome)who visited the pediatric outpatient department of Zhengzhou Hospital of Traditional Chinese Medicine Affiliated to Henan University of Chinese Medicine from June to December 2021 were selected as the research subjects.They were divided into two groups with a random number table,with 60 cases in each group.The control group received oral administration of Xiaoer Chaigui Tuire Granules(小儿柴桂退热颗粒),while the treatment group received sigmoid colon drip of Sanyang Qingjie Ye.Both groups were treated for 2 days and continued to be observed for 24 hours.The onset time of antipyretic effect,complete fever reduction time,frequency of combining with ibuprofen during treatment,clinical efficacy,and adverse reactions were recorded for both groups.Results The effective time and complete fever reduction time of the treatment group were shorter than those of the control group,and the difference between the two groups was statistically significant(P<0.01).The treatment group used ibuprofen less frequently than the control group,and the difference between the two groups was statistically significant(P<0.01).The total effective rate of the control group was 81.67%(49/60),while that of the treatment group was 95.00%(57/60).The dfference in total effective rates between the two groups was statistically significant(P<0.05).The incidence of adverse reactions in the control group was 15.00%(9/60),while in the treatment group it was 8.33%(5/60).There was no statistically significant difference between the two groups(P>0.05).Both groups of adverse reactions were mild and did not affect treatment.Conclusion The treatment of children's febrile symptoms(wind heat syndrome)by sigmoid colon drip of Sanyang Qingjie Ye can improve children's febrile symptoms faster,with faster recovery of body temperature,fewer times of combining with ibuprofen,less adverse reactions,and remarkable efficacy,which is worth to be popularized and applied in clinics.