富血小板血浆局部注射治疗手部创面不愈合的临床疗效观察

Clinical Efficacy of Local Injection of Platelet-rich Plasma in the Treatment of Non-healing Hand Wounds

目的:观察手部创面不愈合治疗中富血小板血浆局部注射的临床疗效。方法:回顾性选取2020年2月-2022年2月本院手部创面不愈合患者100例,依据手术彻底清创术后处理方法分为富血小板血浆局部注射治疗组(富血小板血浆组)、常规换药处理组两组,各50例。统计分析两组疼痛程度、创面愈合情况、瘢痕增生情况、日常自理情况、生活质量、创面生长因子浓度、创面愈合率、创面感染率、临床疗效、换药次数、创面愈合时间、住院时间、住院费用、不良反应发生情况、外观满意度。结果:富血小板血浆组患者的VAS评分、BWAT评分、VSS评分均低于常规换药处理组(P<0.05),ADL评分、SF-36评分、创面VEGF、EGF、TGF-β、PDGF、IGF浓度均高于常规换药处理组(P<0.05),创面愈合率高于常规换药处理组(P<0.05),创面感染率低于常规换药处理组(P<0.05),总有效率高于常规换药处理组(P<0.05),换药次数少于常规换药处理组(P<0.05),创面愈合时间、住院时间均短于常规换药处理组(P<0.05),住院费用低于常规换药处理组(P<0.05),不良反应发生率低于常规换药处理组(P<0.05),外观满意度高于常规换药处理组(P<0.05)。结论:手部创面不愈合治疗中富血小板血浆局部注射的临床疗效较常规换药显著。

Objective:To observe the clinical effect of local injection of platelet-rich plasma in the treatment of hand wound nonunion.Methods:100 patients with nonunion of hand wound in our hospital from February 2020 to February 2022 were retrospectively selected,and were divided into two groups according to the treatment methods after thorough debridement:local injection of platelet-rich plasma group(platelet-rich plasma group)and routine dressing change treatment group,with 50 patients in each group.The degree of pain,wound healing,scar hyperplasia,daily self-care,quality of life,wound growth factor concentration,wound healing rate,wound infection rate,clinical efficacy,dressing change times,wound healing time,hospital stay,hospitalization expenses,adverse reactions,and appearance satisfaction were statistically analyzed in the two groups.Results:The VAS score,BWAT score and VSS score of patients in the platelet-rich plasma group were lower than those in the conventional dressing change treatment group(P<0.05),ADL score,SF-36 score,wound VEGF,EGF,TGF-β、The concentrations of PDGF and IGF were higher than those of the conventional dressing change treatment group(P<0.05),the wound healing rate was higher than that of the conventional dressing change treatment group(P<0.05),the wound infection rate was lower than that of the conventional dressing change treatment group(P<0.05),the total effective rate was higher than that of the conventional dressing change treatment group(P<0.05),the dressing change frequency was lower than that of the conventional dressing change treatment group(P<0.05),and the wound healing time and hospital stay were shorter than that of the conventional dressing change treatment group(P<0.05),The hospitalization cost was lower than that of the conventional dressing change treatment group(P<0.05),the incidence of adverse reactions was lower than that of the conventional dressing change treatment group(P<0.05),and the appearance satisfaction was higher than that of the conventional dressing change treatment group(P<0.05).Conclusion:The clinical effect of local injection of platelet-rich plasma in the treatment of hand wound nonunion is significantly better than that of routine dressing change.