胱抑素C水平与非急性卒中患者缺血性脑白质病变严重程度的相关性研究

Correlation of Cystatin C levels with the Severity of Ischemic White Matter Lesions in Patients with Non-acute Stroke

目的:分析非急性卒中患者胱抑素C水平与缺血性脑白质病变严重程度的相关性。方法:纳入2022年1月至2022年6月在石河子市人民医院住院的非急性卒中患者116例,分析患者临床资料,记录患者相关数据,采用有序Logistic回归分析检测胱抑素C水平与缺血性脑白质病变严重程度的相关性。结果:不同程度的缺血性脑白质病变患者胱抑素C水平存在明显差异(P<0.05),胱抑素C是缺血性脑白质病变严重程度的独立危险因素(OR值55.257);高血压史、受教育程度低、同型半胱氨酸、红细胞分布宽度亦为缺血性脑白质病变独立危险因素。结论:胱抑素C水平与缺血性脑白质病变严重程度独立相关。

Objective:To analyze the correlation between serum cystatin C concentration and the severity of white matter lesions in non-acute stroke patients.Methods:A total of 116 patients hospitalized in Shihezi People's Hospital for non-acute stroke from January 2022 to June 2022 were included in the current study.Clinical data were collected and analyzed;ordinal Logistic regression analysis was employed to examine the correlation between patients′serum cystatin C concentration and the severity of their respective white matter lesions.Results:Difference of statistical significance could be found in the serum cystatin C concentration among patients of ischemic white matter lesions of different severity(P<0.05),which proves to be an independent risk factor for the severity of ischemic white matter lesions(OR=55.257).Hypertension,the lower educational background,serum homocysteine concentration,and red blood cell distribution width are also independent risk factors predictive of the severity thereof.Conclusion:Serum cystatin C is independently correlational to the severity of ischemic white matter lesions.