糖尿病足溃疡患者清创术后创面弱碱性溶液浸泡的治疗效果

Wound immersion with weakly alkaline solution after debridement for refractory diabetic foot ulcer

回顾性选择2019年1月至2022年12月于潍坊市人民医院创伤骨科就诊的糖尿病足溃疡患者44例,根据处理方式不同,分为试验组与对照组,各22例。对照组清创术后使用碘伏消毒后凡士林纱布覆盖创面,试验组术后进行pH为7.5~8.0碱水浸泡,比较两种方法的治疗效果。术后4周试验组创面面积小于对照组[3.15(0,7.60)比6.75(3.50,9.32)cm 2],创面细菌培养阳性比例低于对照组[40.9%(9/22)比72.7%(16/22)],差异均有统计学意义(P<0.05)。12周时两组患者创面愈合率差异无统计学意义[72.7%(16/22)比63.6%(14/22)],但试验组患者的愈合时间明显短于对照组[(6.56±2.68)比(9.50±3.87)周],差异有统计学意义(P<0.05)。提示弱碱性溶液浸泡有助于糖尿病足溃疡病情的改善,促进创面愈合。

A total of 44 patients with diabetic foot ulcers were treated in the Traumatic Orthopedics Department of Weifang People′s Hospital from January 2019 to December 2022.After debridement of foot ulcers the wounds were soaked in alkaline water of pH 7.5-8.0(study group,n=22)or covered with vaseline gauze following iodophor disinfection(control group,n=22).The therapeutic effects of the two methods were compared.Four weeks after debridement,the wound area of study group was smaller than that of control group(3.15(0,7.60)vs.6.75(3.50,9.32)cm2,P<0.05),and the proportion of positive wound bacterial culture was lower than that of control group(40.9%(9/22)vs.72.7%(16/22),P<0.05).At 12 weeks after surgery,there was no statistically significant difference in the wound healing rate between the two groups(72.7%(16/22)vs.63.6%(14/22)),but the healing time of the study group was significantly shorter than that of the control group((6.56±2.68)vs.(9.50±3.87)weeks,P<0.05).It is suggested that immersion of weak alkaline solution is helpful to promote wound healing for patients with diabetic foot ulcers after debridement surgery.