长链非编码RNA在儿童肺部感染中的研究进展

Advance in long non-coding RNAs in children with pulmonary infection

肺部感染是儿童最常见的疾病,也是引起儿童死亡的重要原因,引起呼肺部感染的病原体多种多样,目前以药物治疗为主。长链非编码RNA(LncRNAs)是指转录组中不翻译为蛋白质的RNA分子,既往常被认为是无用的,随着研究的深入,学者们发现LncRNAs在基因表达中有着重要的调控作用。LncRNAs在儿童肺部感染过程中发挥重要作用,通过与宿主或病原体的相互作用参与疾病的发生和发展。大部分LncRNAs发挥功能的机制是通过竞争性结合miRNA来调节靶向基因的表达或靶向通路的活化,有些LncRNAs可作为预测因子帮助我们了解疾病发展的动向。目前,关于LncRNAs在儿童疾病中的研究较少,本文对LncRNAs在儿童呼吸道感染中发挥的作用进行综述,致力于为临床工作探索新的检测标志物及治疗方向。

Respiratory tract infection is the most common disease in children and an important cause of death in children.There are various pathogens causing respiratory tract infection,and drug therapy is the main method at present.Long non-coding RNAs(LncRNAs)are RNA mole-cules in the transcriptome that can't be translated into proteins,which is considered useless in the past.With the deepening of research,scholars have found that LncRNAs play an important role in the regulation of gene expression,and participate in the occurrence and development of diseases through interaction with host or pathogen in the process of pulmonary infection in children.The mechanism by which most LncRNAs function is to regulate the expression of targeted genes or the activation of targeted pathways through competitive binding of miRNAs.Some LncRNAs can be used as predictors to help us understand the trend of disease development.There are still few studies on LncRNAs in children's diseases currently,this article reviews the function of LncRNAs in children's respiratory tract infections,aiming to explore new detection markers and treatment direc-tions for clinical work.