小檗碱抗胃癌的药理作用及其机制研究进展

Research Progress in the Pharmacological Effects and Mechanisms of Berberine against Gastric Cancer

胃癌的发病率和死亡率在我国各种恶性肿瘤中均位居第三,是威胁人民生命健康的重要杀手。小檗碱除具有抗炎、抗感染、调节心血管等作用外,对肝癌、结直肠癌、脑瘤、头颈部肿瘤、泌尿系肿瘤等也有较好的作用,因而可能是一个潜在的抗肿瘤药物。该文主要从小檗碱预防胃癌的发生,以及对SGC7901、BGC-823、MKN-45等人胃癌细胞的抑制和诱导凋亡等方面进行了综述,以期为小檗碱的进一步临床开发提供参考。

Gastric cancer is an important killer that threatens people's life and health,and its morbidity and mortality rank third among various malignant tumors in China.In addition to its anti-inflammatory,anti-infective,and cardiovascular regulating effects,berberine has good effects on liver cancer,colorectal cancer,brain tumors,head and neck tumors,urinary system tumors,etc.Therefore,it may be a potential anti-tumor drug.In this article,the prevention of gastric cancer with berberine,and the inhibition and induction of apoptosis of human gastric cancer cells such as SGC7901,BGC-823,and MKN-45 are mainly reviewed to provide a reference for the clinical development of berberine in the future.