1例使用注射用头孢唑肟钠致患者全身肌肉痛的临床分析

Clinical Analysis of a Patient with Systemic Muscle Pain Caused by Ceftizoxime Sodium for Injection

目的:分析1例患者使用注射用头孢唑肟钠后出现全身肌肉痛的发生和处置过程,为临床头孢唑肟的用药安全提供参考。方法与结果:患者因反复中上腹闷痛不适20余天,且在外院被检查出胃癌(贲门腺癌),而转诊至我院胃肠外科;临床考虑择期手术,遂预防性使用了注射用头孢唑肟钠;然而,用药后不久,患者诉全身肌肉酸痛、盗汗、关节不适、腰背部大范围疼痛,且心率达104次/min,视觉模拟评分(visualanaloguescale,VAS)达8分;综合患者既往病情和当前用药情况,初步怀疑为注射用头孢唑肟钠所致的药物不良反应,遂停用注射用头孢唑肟钠;很快,患者诉全身肌痛缓解,VAS降为3分,遂认定患者的肌肉痛很可能就是注射用头孢唑肟钠所致。结论:注射用头孢唑肟钠所致的全身肌肉酸痛在临床中鲜有报道,临床药师在开展药学实践时应综合患者的病情和用药情况,以协助医生进行准确判断,从而有效处置,保障患者的用药安全。

Objective:To analyze the occurrence and treatment process of systemic muscle pain in one patient after using ceftizoxime sodium for Injection,and to provide reference for clinical medication safety of ceftizoxime.Methods and Results:The patient was referred to the gastrointestinal surgery department of our hospital because of repeated middle and upper abdominal pain and discomfort for more than 20 days,and gastric cancer(cardiac adenocarcinoma)detected by other hospital.The clinic considered elective surgery,so ceftizoxime sodium for Injection was preventively used.However,shortly after medication,the patient complained of systemic muscle soreness,night sweating,joint discomfort,and extensive pain in the back and waist,with a heart rate of 104 times/min and a visual analysis scale(VAS)of 8 points.Based on the previous condition and current medication of the patient,it was initially suspected that the adverse drug reactions were caused by ceftizoxime sodium for Injection,so ceftizoxime sodium for Injection was stopped.Soon,the patient complained that the systemic myalgia was relieved and VAS was reduced to 3 points,so it was determined that the myalgia was probably caused by ceftizoxime sodium for Injection.Conclusion:Systemic muscle pain caused by ceftizoxime sodium for Injection is rarely reported in clinical practice.Clinical pharmacists should integrate patients'condition and medication when carrying out pharmaceutical practice to help doctors make accurate judgments,so as to effectively deal with situations and ensure the medication safety of patients.