多奈哌齐对阿尔茨海默病患者智力状态认知功能及氧化应激的改善作用

Improvement of Intellectual Status,Cognitive Function and Oxidative Stress in Alzheimer's Disease Patients Treated with Donepezil

目的探讨多奈哌齐对阿尔茨海默病(Alzheimer’s disease,AD)患者智力状态、认知功能及氧化应激的改善作用。方法选择2020年6月—2023年6月沈阳医学院第二附属医院收治的AD患者60例,随机分为对照组和观察组各30例。两组均接受生活方式干预和改善脑代谢、营养脑神经药物治疗;观察组在此基础上增加多奈哌齐进行治疗。比较两组治疗后智力状态、认知功能及氧化应激的改善作用。结果观察组治疗3个月和6个月后,简易精神状态量表评分高于对照组,而阿尔茨海默病评定量表认知分量表评分低于对照组,差异有统计学意义(P<0.05)。两组治疗6个月后,观察组超氧化物歧化酶、谷胱甘肽过氧化物酶水平高于对照组;而丙二醛、同型半胱氨酸、血尿酸水平低于对照组,差异有统计学意义(P<0.05)。结论多奈哌齐可以进一步改善AD患者的智力状态和认知功能,并且能够有效调节氧化应激平衡。

Objective To explore the improvement effect of donepezil on intellectual status,cognitive function,and oxidative stress in patients with Alzheimer's disease(AD).Methods Sixty AD patients admitted to the Second Affiliated Hospital of Shenyang Medical College from June 2020 to June 2023 were randomly divided into a control group and an observation group,with 30 cases in each group.Both groups received lifestyle intervention and treatment with drugs to improve brain metabolism and nourish brain nerves.On this basis,the observation group added donepezil for treatment.The improvement effects of intellectual status,cognitive function,and oxidative stress between two groups after treatment were compared.Results After 3 and 6 months of treatment,the observation group had significantly higher scores on the mini-mental state examination than the control group,and significantly lower scores on the Alzheimer's disease assessment scale-cognitive component than the control group(P<0.05).After 6 months of treatment,the levels of superoxide dismutase and glutathione peroxidase in the observation group were significantly higher than those in the control group,while the levels of malondialdehyde,homocysteine and serum uric acid in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Donepezil can further improve the intellectual status and cognitive function of AD patients,and can effectively regulate oxidative stress balance.