维生素及联合钙摄入与原发骨质疏松症风险关联性研究进展

Research Progress on the Association between Vitamin,Calciumand Combined Intake and the Risk of Primary Osteoporosis

研究表明,维生素及联合钙摄入与骨质疏松症(osteoporosis, OP)存在关联,但尚缺乏对相关性研究证据的有效整合。通过梳理相关文献,对维生素及联合钙摄入与原发性OP发生风险的关联研究进行综述。分析发现,膳食或血清维生素D、E、K、C和B族维生素水平与OP相关,但维生素A与OP风险关联尚无一致结论。多种维生素联合摄入、钙+维生素D、钙+维生素D+维生素K协同摄入对OP有保护作用。相关卫生政策和临床诊疗指南对某些维生素的参考摄入量或治疗剂量进行了规定,但“因地制宜”的相关卫生政策较少。

Studies have shown that vitamin and combined calcium intake is associated with osteoporosis(OP),but there is a lack of effective integration of relevant research evidence.This paper reviews the correlation between vitamin,calcium combined intake and the risk of primary OP by combing relevant literature.The analysis found that dietary or serum vitamin D,E,K,C and B levels were associated with OP,but there was no consistent association between vitamin A and OP risk.Combined intake of multiple vitamins,synergistic intake of calcium and vitamin D,and synergistic intake of calcium,VD and VK have protective effects on OP.Relevant health policies and clinical guidelines stipulated the reference intake or therapeutic dose of each vitamin,but there is a lack of relevant health policies that"adapt to local conditions".