巨噬细胞在葡萄膜炎免疫调节治疗机制中的研究进展

Advances in the role of macrophages in the immunoregulatory treatment mechanism of uveitis

葡萄膜炎是一类常见的累及葡萄膜、视网膜、视网膜血管及玻璃体的顽固性致盲性的炎性疾病,它的发生与其各细胞亚群免疫机制失衡相关,巨噬细胞在机体先天免疫系统中起核心作用,能将人体内炎性致病菌有效清除,在应激反应中,巨噬细胞可通过极化参与机体的病原体反应和炎症调节,因此,为了系统地了解巨噬细胞极化平衡在葡萄膜炎的免疫调节机制中发挥的重要作用,文章主要通过对巨噬细胞的来源认识、机制通路的研究从而将其与葡萄膜炎疾病发生发展相联系,最后针对相关诊疗进展进行综述。

Uveitis is a common and refractory inflammatory blinding disease involving the uvea,retina,retinal vessels,and vitreous body.Its occurrence is related to the imbalance of immune mechanisms in various cell subpopulations.Macrophages play a central role in the body’s innate immune system and can effectively clear pathogenic bacteria from the body.In stress responses,macrophages can participate in the body’s pathogen response and inflammation regulation through polarization.Therefore,in order to systematically understand the important role of macrophage polarization balance in the immune regulation mechanism of uveitis,this article mainly links it with the occurrence and development of uveitis disease through the study of the source recognition of macrophages and the mechanism pathway,and finally summarizes the progress of related diagnosis and treatment.