孕晚期血清sTREM-1、HBD2水平与B族链球菌感染顺产孕妇新生儿结局关系分析

Relationship between serum sTREM-1 and HBD2 levels in late pregnancy and the neonatal outcomes of natural delivered pregnant women with B group Streptococcus infection during late pregnancy

目的探究孕晚期血清髓样细胞触发受体-1(sTREM-1)、β防御素2(HBD2)水平与B族链球菌(GBS)感染顺产孕妇新生儿结局的关系。方法选取2021年6月-2023年7月在本院生产的180例妊娠晚期的顺产孕妇患者作为观察对象,根据是否发生GBS感染,将其分为感染组(85例)和未感染组(95例)。根据感染组新生儿结局,分为结局良好组(60例)和不良结局组(25例)。比较各组血清sTREM-1、HBD2水平。ROC分析血清sTREM-1、HBD2水平对新生儿不良结局的预测价值。Logistic多因素回归分析影响新生儿不良结局的因素。结果感染组血清sTREM-1、HBD2水平比未感染组高(P<0.05)。GBS感染孕妇分娩的新生儿中检测出25例出现不良结局,新生儿不良结局发生率为29.41%。不良结局组血清sTREM-1、HBD2水平比结局良好组高(P<0.05)。ROC分析显示,sTREM-1、HBD2评估新生儿不良结局的AUC是0.815(95%CI:0.718~0.912)、0.801(95%CI:0.702~0.901),二者联合预测的AUC为0.919(95%CI:0.849~0.968),优于二者单独预测(Z=1.784、1.994,P<0.05)。Logistic结果显示,sTREM-1、HBD2是新生儿不良结局的影响因素(P<0.05)。结论检测孕晚期GBS感染顺产孕妇的血清sTREM-1、HBD2水平有利于对新生儿结局进行判断。

Objective To investigate the relationship between serum levels of soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and beta-defensin 2(HBD2)in late pregnancy and the neonatal outcomes of natural delivered pregnant women with group B Streptococcus(GBS)infection during late pregnancy.Methods A total of 180 pregnant women who gave birth in our hospital from June 2021 to July 2023 were regarded as the observation subjects.They were separated into an infected group(85 cases)and an uninfected group(95 cases)based on whether GBS infection occurred.According to the outcome of newborns in the infected group,they were separated into a good outcome group(60 cases)and an adverse outcome group(25 cases).The serum levels of sTREM-1 and HBD2 in each group were compared.ROC was applied to analyze the predictive value of serum sTREM-1 and HBD2 levels for adverse outcomes in newborns.Logistic multiple factor regression was applied to analyze the factors influencing adverse outcomes in newborns.Results The serum levels of sTREM-1 and HBD2 in the infected group were higher than those in the uninfected group(P<0.05).25 cases of adverse outcomes were detected in newborns born to pregnant women with GBS infection,with an incidence rate of 29.41%.The serum levels of sTREM-1 and HBD2 in the adverse outcome group were higher than in the good outcome group(P<0.05).ROC analysis showed that the AUC for assessing adverse outcomes in newborns using sTREM-1 and HBD2 was 0.815(95%CI:0.718-0.912)and 0.801(95%CI:0.702-0.901),respectively,the AUC predicted by the combination of the two was 0.919(95%CI:0.849-0.968),which was better than the single prediction of the two(Z=1.784,1.994,P<0.05).Logistic results showed that sTREM-1 and HBD2 were the influencing factors for adverse outcomes in newborns(P<0.05).Conclusion Testing the serum levels of sTREM-1 and HBD2 in natural delivered pregnant women with GBS infection during late pregnancy is beneficial for assessing neonatal outcomes.