外周血cfDNA液体活检技术在肝棘球蚴病诊治中的应用进展

Application of peripheral blood cfDNA liquid biopsy in diagnosis and treatment of hepatic echinococcosis

循环游离DNA(cfDNA)是主要存在于血液以及其他体液的核酸片段,包括细胞核DNA和线粒体DNA。cfDNA作为一种“液体活检”技术,在肝棘球蚴病的诊断、预后和疗效监测等方面均有重要的应用价值,有望成为新一代的肝棘球蚴病诊治新方法。

Circulating cell-free DNA (cfDNA) is a nucleic acid fragment mainly existing in blood and other body fluids,including nuclear DNA and mitochondrial DNA.As a "liquid biopsy" technique,cfDNA has high application value in the diagnosis,prognosis and clinical efficacy monitoring of hepatic echinococcosis,which is expected to become a new-generation diagnosis and treatment approach for hepatic echinococcosis.