肝脏缺血-再灌注损伤与cGAS-STING信号通路

Liver ischemia-reperfusion injury and cGAS-STING signaling pathway

肝脏缺血-再灌注损伤(IRI)通常发生在肝脏手术(肝移植、肝切除)以及各种循环休克事件中,是术后肝功能不全、疾病转归及患者预后不良等不可避免的临床问题。环磷酸鸟苷-磷酸腺苷合成酶(cGAS)是近些年来新发现的关键DNA受体,是一种感应细胞内DNA损伤的酶,当细胞内DNA受损时,会被激活cGAS-STING信号通路并产生相关免疫因子,诱导机体炎症免疫激活,推动炎症性肝细胞损伤。本文就cGAS-STING信号通路的激活过程及其在肝脏IRI中相关作用与机制展开综述。

Liver ischemia-reperfusion injury (IRI) mainly occurs in liver surgery (liver transplantation,hepatectomy) and multiple circulatory shock events,which is an inevitable clinical problem for postoperative liver dysfunction,disease outcome and poor prognosis of patients,etc.As a newly-discovered key DNA receptor in recent years,cyclic GMP-AMP synthase (cGAS) is an endogenous DNA sensor.When intracellular DNA damage occurs,cGAS-STING signaling pathway will be activated and relevant immune cytokines will be generated,which will induce inflammatory immune activation and aggravate inflammatory hepatocyte damage.In this article,the activation process of cGAS-STING signaling pathway and its role and mechanism in liver IRI were reviewed.