索拉非尼在急性髓系白血病中的应用

Therapeutic application of sorafenib in acute myeloid leukemia

随着多种靶向药物的问世,急性髓系白血病(acute myeloid leukemia,AML)逐渐进入靶向治疗时代。其中索拉非尼作为一种以靶向FLT3-ITD为主的多激酶抑制剂,在AML治疗中得到广泛应用,主要用于FLT3-ITD+AML的治疗,特别是移植后的维持治疗。另外,鉴于索拉非尼的多激酶抑制特征,也有不少研究尝试将其用于FLT3野生组AML的治疗。本文综述了索拉非尼在AML中的治疗应用及相关研究进展。

With the emergence of a variety of targeted drugs,acute myeloid leukemia(AML)has gradually entered an era of targeted therapy.As a multikinase inhibitor,mainly targeting FLT3-ITD,sorafenib is widely used in the treatment of AML,and it is mainly used for FLT3-ITD mutated AML,especially for the maintenance therapy after allogeneic hematopoietic stem cell transplantation.Besides,based on its multikinase inhibition,many studies have also tried to use sorafenib for the treatment of AML with FLT3-WT.Therefore,this review summarizes the therapeutic application and the progress of sorafenib in AML with FLT3-ITD mutation or FLT3-WT.