衰老相关标志物的研究进展

Research progress of aging-related biomarkers

老龄化问题逐渐成为老年医学领域的重要话题,探索衰老相关标志物为采取干预措施延缓和逆转衰老提供依据。近年来已有大量细胞水平(衰老机制、组学)与个体水平(复合型指标、功能指标)的衰老标志物,本文系统论述了细胞和个体水平重要生物标志物的特点和适用场景,并概述了衰老标志物的比较研究。未来的研究可考虑综合各层次多维度的衰老标志物,以更准确、可靠地评估衰老。此外,组学数据对于进一步挖掘衰老标志物具有较大潜力。

Aging has become an increasingly important topic in the field of geriatrics,with the exploration of aging-related biomarkers providing a foundation for interventions aimed at delaying and reversing aging.Over the years,numerous biomarkers have been developed at both the cellular level(aging mechanisms,histology)and individual level(composite biomarkers,functional biomarkers).This article systematically discusses the characteristics and application scenarios of significant biomarkers at these two levels,and also outlines comparative studies conducted on aging biomarkers.Future research should consider synthesizing multidimensional aging biomarkers at all levels to achieve a more accurate and reliable assessment of aging.Furthermore,there is great potential for further exploration of aging biomarkers through the analysis of histologic data.