多巴胺在帕金森病相关性疼痛中的地位及研究进展

The role of dopamine in Parkinson's disease-related pain and research progress

疼痛是帕金森病(PD)中非常重要的非运动症状之一,严重影响患者生活质量。PD相关性疼痛的中枢处理机制包括多巴胺能系统和非多巴胺能系统两方面。近年来很多研究发现多巴胺参与急慢性疼痛的感知、传导及调控,认为多巴胺是调节疼痛感觉的关键神经递质。为进一步明确多巴胺在PD相关性疼痛中的作用,本文综合文献,从PD疼痛相关结构及多巴胺能神经回路、细胞分子机制多个层面,系统地阐述了多巴胺在PD相关性疼痛中的作用,并分析展望了PD相关性疼痛未来应重点研究的方向。

Pain is one of the most important non-motor symptoms of Parkinson's disease(PD)and seriously affects life quality.Mechanisms underlying how the central nervous system processes PD-related pain involve both the dopaminergic and non-dopaminergic systems.In recent years,numerous studies have demonstrated the involvement of dopamine in the perception,conduction,and regulation of both acute and chronic pain.Dopamine is believed to be a crucial neurotransmitter in the regulation of pain sensation.In order to elucidate the role of dopamine in PD-associated pain,this paper systematically addressed this issue from several perspectives,including structures and dopaminergic neural circuits implicated in PD-related pain,and cellular and molecular mechanisms.Additionally,potential avenues for future research on PD-related pain are outlined.