洛美沙星联合曲安奈德治疗小儿急性中耳炎的疗效及其对血清miR-203a、miR-155的影响

Efficacy of Lomefloxacin combined with triamcinolone olone in the treatment of acute otitis media in children and its influence on serum miR-203a and miR-155

目的 研究洛美沙星联合曲安奈德治疗小儿急性中耳炎(AOM)的疗效及其对血清miR-203a、miR-155的影响。方法 根据治疗方法不同将2021年6月至2023年6月该院AOM患儿134例分为对照组、联合组,各67例。对照组采用曲安奈德治疗,联合组采用洛美沙星+曲安奈德治疗。比较2组临床疗效、病情恢复时间、炎症因子[白细胞介素-8(IL-8)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)]、血清miR-203a、miR-155水平、致病菌清除率及不良反应发生率。结果 联合组临床总有效率[92.54%(62/67)]高于对照组[80.60%(54/67)],差异有统计学意义(P<0.05);治疗后联合组听力恢复时间、鼓膜充血消退时间、耳痛消退时间、退热时间均短于对照组,差异均有统计学意义(P<0.05);与治疗前相比,治疗后2组IL-8、TNF-α、PCT、miR-155、miR-203a均明显降低,且联合组明显低于对照组,差异均有统计学意义(P<0.05);联合组致病菌清除率[91.04%(61/67)]高于对照组[77.61%(52/67)],差异有统计学意义(P<0.05);2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 洛美沙星联合曲安奈德治疗AOM疗效显著,可通过下调miR-203a、miR-155水平,减轻炎症反应,还可提高致病菌清除率,促进病情恢复,安全性高。

Objective To investigate the efficacy of lomefloxacin combined with triamcinolone olone in the treatment of acute otitis media(AOM)in children and the effects on serum miR-203a and miR-155.Methods According to different treatment methods,134 children with AOM in our hospital from June 2021 to June 2023 were divided into the control group and the combination group,with 67 cases in each group.The control group was treated with triamcinolone and the combination group was treated with lomefloxacin and triamcinolone.The clinical efficacy,recovery time,inflammatory factors[interleukin-8(IL-8),procalcitonin(PCT),tumor necrosis factor(TNF-α)],serum levels of miR-203a and miR-155,pathogenic bacteria clearance and adverse reactions were compared between the two groups.Results The total effective rate of combined group[92.54%(62/67)]was higher than that of control group[80.60%(54/67)],the difference was statistically significant(P<0.05).Compared with the control group,the hearing recovery time,tympanic congestion fading time,earache fading time and fever fading time of the combined group were shorter after treatment,the difference were statistically significant(P<0.05).Compared with before treatment,IL-8,TNF-α,PCT,miR-155 and miR-203a in the combination group were significantly decreased after treatment(P<0.05).The pathogenic bacteria clearance rate of the combined group[91.04%(61/67)]was higher than that of the control group[77.61%(52/67)],the difference was statistically significant(P<0.05),and there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Lomefloxacin combined with triamcinolone in the treatment of AOM is effective,can reduce inflammation by down-regulating the levels of miR-203a and miR-155,can also improve the clearance rate of pathogenic bacteria,promote disease recovery,and has high safety.