Notch通路在类风湿关节炎中的研究进展

Research Progress of Notch Signaling Pathway in Rheumatoid Arthritis

Notch信号通路调控细胞发育、分化、增殖和凋亡,是决定细胞命运最重要的通路之一。研究发现,Notch通路参与类风湿关节炎(RA)的发生发展。该文简述Notch通路的组成、激活途径、功能和在RA中的作用,分析Notch通路在巨噬细胞、破骨细胞、血管内皮细胞、淋巴细胞、成纤维样滑膜细胞中的研究进展。认为进一步探索Notch通路在RA中的作用机制,可为药物研发提供方向,同时为RA临床治疗提供新靶点。

Notch signaling pathway regulates cell development,differentiation,proliferation,and apoptosis,one of the most important pathways that determine cell fate.Research has found that the Notch pathway is involved in developing rheumatoid arthritis(RA).In this article,we reviewed the composition,activation pathway,function,and role of the Notch pathway in RA,and analyzed the research progress of the Notch pathway in macrophages,osteoclasts,vascular endothelial cells,lymphocytes,and fibroblast-like synovial cells.Further exploration of the mechanism of the Notch pathway in RA can provide direction for clinical drug development and new targets for treating RA.